P2RX2 and GABRA1

Number of citations of the paper that reports this interaction (PubMedID 21343285)
74

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		P2RX2	GABRA1
Description		purinergic receptor P2X 2	gamma-aminobutyric acid type A receptor subunit alpha1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Synapse Postsynapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA Receptor Complex GABA-A Receptor Complex
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Ligand-gated Monoatomic Ion Channel Activity Identical Protein Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Promethazine	Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Topiramate Etomidate Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Picrotoxin Methohexital Chlordiazepoxide Chlordiazepoxide Amoxapine Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Progabide Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Zaleplon Methoxyflurane Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Methyprylon Thiamylal Halothane Halothane Phenobarbital Desflurane Zopiclone Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Clomethiazole Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Body mass index ( 26426971)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Gait speed in old age ( 28077804)
Interacting Genes		4 interacting genes: GABRA1 GABRR1 P2RX1 P2RX3	6 interacting genes: DRD4 P2RX2 PPP3CA PRKCD PRKCG UBQLN1
Entrez ID		22953	2554
HPRD ID		15984	00662
Ensembl ID		ENSG00000187848	ENSG00000022355
Uniprot IDs		Q32MC3 Q9UBL9	A8K177 P14867
PDB IDs			6CDU 6D1S 6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7PBD 7PBZ 7PC0 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG 9H9E
Enriched GO Terms of Interacting Partners?		Monoatomic Ion Channel Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Regulation Of Membrane Potential GABA Receptor Activity Regulation Of Postsynaptic Membrane Potential Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Cell-cell Signaling Signaling Cell Communication Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Monoatomic Ion Transport Postsynaptic Membrane Purinergic Nucleotide Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Transmembrane Transport Response To ATP Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Complex Positive Regulation Of Calcium Ion Transmembrane Transport Excitatory Postsynaptic Potential Chloride Channel Activity Modulation Of Chemical Synaptic Transmission Chloride Transmembrane Transport Positive Regulation Of Calcium Ion Transport GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Suramin Binding Regulation Of Biological Quality GABA Receptor Complex Serotonin Secretion By Platelet Positive Regulation Of Monoatomic Ion Transport Calcium Ion Transmembrane Transport Serotonin Secretion Insemination	Regulation Of Transport Multicellular Organismal Response To Stress Regulation Of Postsynaptic Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Angiotensin Skeletal Muscle Fiber Development Regulation Of Calcium Ion Transport Myotube Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Cell Communication Positive Regulation Of Transport Response To Stress Positive Regulation Of Signaling Regulation Of Endocytosis Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Excitatory Postsynaptic Potential Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Negative Regulation Of Angiotensin-activated Signaling Pathway Enzyme Binding Striated Muscle Cell Development Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Methionine Adenosyltransferase Regulator Activity Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Neurotransmitter Secretion Regulation Of Membrane Potential Regulation Of Calcium-mediated Signaling Muscle Cell Development Positive Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sphingomyelin Catabolic Process Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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