GABRR1 and MAP1B

Number of citations of the paper that reports this interaction (PubMedID 11102469)
51

Data Source:
HPRD (in vivo)

		GABRR1	MAP1B
Description		gamma-aminobutyric acid type A receptor subunit rho1	microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Presynaptic Membrane Synapse Postsynaptic Membrane Intracellular Vesicle Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex	Photoreceptor Outer Segment Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Cell Projection Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Identical Protein Binding Protein-containing Complex Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Nervous System Development Axonogenesis Synapse Assembly Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Carbohydrate Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Neuron Projection Development Response To Nutrient Levels Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Intracellular Transport Mitochondrion Transport Along Microtubule Neuron Development Axon Extension Response To Axon Injury Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Odontoblast Differentiation Regulation Of Postsynapse Assembly
Pathways		GABA receptor activation	RSV-host interactions
Drugs		Lindane Picrotoxin Fludiazepam TPMPA
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	36 interacting genes: ACTB ANP32A ARHGEF11 CREBBP CSNK2A1 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HMGB1 HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NEIL3 NXF1 NXF2 PAFAH1B1 PRKAR1A RASSF1 RNF10 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2 VHL
Entrez ID		2569	4131
HPRD ID		15921	01139
Ensembl ID		ENSG00000146276	ENSG00000131711
Uniprot IDs		P24046	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs		8OP9 8OQ6 8OQ7 8OQ8 8OQA 8RH4 8RH7 8RH8 8RH9 8RHG
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity System Process Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Kinase Activity Regulation Of Steroid Biosynthetic Process Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Steroid Metabolic Process Protein Phosphorylation ATP Binding Plasma Membrane Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Transport Response To Carbohydrate Positive Regulation Of Cholesterol Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cholesterol Biosynthetic Process Nucleotide Binding Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Postsynapse Protein Catabolic Process Dendrite Development Regulation Of Intracellular Signal Transduction Regulation Of Muscle System Process Sperm Midpiece Regulation Of Cholesterol Metabolic Process Protein Targeting To Vacuole Cell Communication Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Intracellular Transport Regulation Of Platelet Activation Positive Regulation Of Calcium-mediated Signaling Response To Stress Induction Of Synaptic Plasticity By Chemical Substance	Tau Protein Binding Positive Regulation Of Cell Communication Cellular Response To Stress Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Microtubule Associated Complex Axon Regulation Of Norepinephrine Uptake Regulation Of Biological Quality JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Transporter Regulator Activity Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Localization Negative Regulation Of Gene Expression Synapse Glutamatergic Synapse Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Protein Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Trans-synaptic Signaling Synaptic Signaling Modulation Of Chemical Synaptic Transmission Nuclear RNA Export Factor Complex Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Substantia Nigra Development Regulation Of Apoptotic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process
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