P2RX2 and P2RX3

Number of citations of the paper that reports this interaction (PubMedID 7566120)
0

Data Source:
HPRD (in vitro)

		P2RX2	P2RX3
Description		purinergic receptor P2X 2	purinergic receptor P2X 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Synapse Postsynapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Axon Neuron Projection Receptor Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynapse
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Ligand-gated Monoatomic Ion Channel Activity Identical Protein Binding	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport	Response To Hypoxia Monoatomic Ion Transport Monoatomic Cation Transport Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Response To Temperature Stimulus Response To Heat Response To Cold Response To Mechanical Stimulus Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Establishment Of Localization In Cell Excitatory Postsynaptic Potential Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To ATP Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine	Promethazine
Diseases
GWAS		Body mass index ( 26426971)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Eosinophil percentage of white cells ( 27863252) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Low high density lipoprotein cholesterol levels ( 26879886) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: GABRA1 GABRR1 P2RX1 P2RX3	1 interacting genes: P2RX2
Entrez ID		22953	5024
HPRD ID		15984	09016
Ensembl ID		ENSG00000187848	ENSG00000109991
Uniprot IDs		Q32MC3 Q9UBL9	P56373
PDB IDs			5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT 5YVE 6AH4 6AH5 9IK1
Enriched GO Terms of Interacting Partners?		Monoatomic Ion Channel Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Regulation Of Membrane Potential GABA Receptor Activity Regulation Of Postsynaptic Membrane Potential Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Cell-cell Signaling Signaling Cell Communication Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Monoatomic Ion Transport Postsynaptic Membrane Purinergic Nucleotide Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Transmembrane Transport Response To ATP Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Complex Positive Regulation Of Calcium Ion Transmembrane Transport Excitatory Postsynaptic Potential Chloride Channel Activity Modulation Of Chemical Synaptic Transmission Chloride Transmembrane Transport Positive Regulation Of Calcium Ion Transport GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Suramin Binding Regulation Of Biological Quality GABA Receptor Complex Serotonin Secretion By Platelet Positive Regulation Of Monoatomic Ion Transport Calcium Ion Transmembrane Transport Serotonin Secretion Insemination	Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Purinergic Nucleotide Receptor Activity Peristalsis Extracellularly ATP-gated Monoatomic Cation Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Purinergic Nucleotide Receptor Signaling Pathway Neuronal Dense Core Vesicle Regulation Of Calcium Ion Transport Into Cytosol Behavioral Response To Pain Skeletal Muscle Fiber Development Sensory Perception Of Taste Ligand-gated Monoatomic Ion Channel Activity Response To ATP Neuromuscular Synaptic Transmission Myotube Cell Development Neuromuscular Junction Development Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Excitatory Postsynaptic Potential Response To Ischemia Positive Regulation Of Calcium Ion Transmembrane Transport Striated Muscle Cell Development Muscle Cell Development Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Postsynaptic Membrane Potential Sensory Perception Of Chemical Stimulus Detection Of Chemical Stimulus Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Response To Carbohydrate Monoatomic Ion Channel Activity Positive Regulation Of Monoatomic Ion Transport Receptor Complex Calcium Ion Transmembrane Transport Muscle Contraction Regulation Of Calcium Ion Transport Postsynapse Muscle System Process Detection Of Stimulus Calcium Ion Transport Synapse Organization Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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