GABRB1 and UBQLN1

Number of citations of the paper that reports this interaction (PMID 11528422)
49

Data Source:
BioGRID (two hybrid)

		GABRB1	UBQLN1
Gene Name		gamma-aminobutyric acid (GABA) A receptor, beta 1	ubiquilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA-A Receptor Complex	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Ligand-gated Ion Channel Activity	Protein Binding Kinase Binding Protein Domain Specific Binding
	Biological Process	Transport Ion Transport Signal Transduction Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA UBQLN1	151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343
Entrez ID		2560	29979
HPRD ID		15924	05440
Ensembl ID		ENSG00000163288	ENSG00000135018
Uniprot IDs		P18505	Q9UMX0
PDB IDs			2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Stimulus Interleukin-8 Biosynthetic Process Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Signal Transduction Regulation Of Cytokine Production Regulation Of Apoptotic Process Regulation Of Cell Death Hypomethylation Of CpG Island Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Response To Stimulus Positive Regulation Of Immune Response Regulation Of Signaling Signal Transduction Phosphatidylinositol-mediated Signaling Positive Regulation Of Metabolic Process Signaling Intracellular Signal Transduction Interleukin-8 Production Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Cell Communication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Cellular Protein Metabolic Process Amacrine Cell Differentiation Positive Regulation Of Protein Kinase A Signaling Regulation Of Immune Response Positive Regulation Of Mitochondrial Translation Regulation Of Genetic Imprinting Positive Regulation Of Immune System Process Positive Regulation Of Dendritic Cell Chemotaxis Regulation Of Protein Metabolic Process Mature Ribosome Assembly Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of RIG-I Signaling Pathway Regulation Of Mitochondrial Translation Negative Regulation Of Viral-induced Cytoplasmic Pattern Recognition Receptor Signaling Pathway Receptor Recycling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of RIG-I Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Anoikis Positive Regulation Of Cytokine Production Blood Coagulation, Intrinsic Pathway	Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		atp5d bear behaviors build cessation chronically clustering diethylamide drd2 hyperactivity illnesses krox20 lsd lysergic medial mpfc ndufa1 neurogenetic neuropeptide neurotransmission npy persist prefrontal qpcr schizophrenia seq sucrose underlie validate	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Difference) ?		atp5d bear behaviors build cessation chronically clustering diethylamide drd2 hyperactivity illnesses krox20 lsd lysergic medial mpfc ndufa1 neurogenetic neuropeptide neurotransmission npy persist prefrontal qpcr schizophrenia seq sucrose underlie validate	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
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