GABRB1 and AKAP5

Number of citations of the paper that reports this interaction (PubMedID 12595241)
0

Data Source:
HPRD (in vitro)

		GABRB1	AKAP5
Description		gamma-aminobutyric acid type A receptor subunit beta1	A-kinase anchoring protein 5
Image
GO Annotations	Cellular Component	Nuclear Envelope Plasma Membrane Membrane Dendrite Chloride Channel Complex Receptor Complex Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Endosome Cytosol Plasma Membrane Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Chloride Channel Activity Ligand-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity GABA Receptor Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Response To Toxic Substance Central Nervous System Neuron Development Response To Progesterone Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Ovulation Cycle Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide gamma-Hydroxybutyric acid Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Adventurousness ( 30643258) Cervical cancer ( 28806749) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		7 interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA UBQLN1	21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1
Entrez ID		2560	9495
HPRD ID		15924	05255
Ensembl ID		ENSG00000163288	ENSG00000179841
Uniprot IDs		P18505 X5DNL6	P24588 Q6PG46
PDB IDs		9CTV 9CXB 9CXD	2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Intracellular Signal Transduction Activation Of Immune Response GABA Receptor Binding Regulation Of Intracellular Signal Transduction Protein Kinase A Regulatory Subunit Binding Regulation Of Macroautophagy Positive Regulation Of Immune Response Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Signal Transduction Intracellular Signaling Cassette Adrenergic Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Autophagy Positive Regulation Of Immune System Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Localization To Membrane Regulation Of Innate Immune Response Kininogen Binding GABA-ergic Synapse Deoxyribonuclease Inhibitor Activity Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling T Cell Receptor Signaling Pathway Response To Butyrate Cellular Response To Hydrostatic Pressure Positive Regulation Of Endosome To Plasma Membrane Protein Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Response To Stress C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of MDA-5 Signaling Pathway Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Symmetric Synapse Endomembrane System Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitochondrial Ribosome Binding Cytosolic Ribosome Assembly Negative Regulation Of RIG-I Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Mitochondrial RNA Catabolic Process	Regulation Of Membrane Potential Intracellular Signal Transduction Response To Metal Ion Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction CAMP-dependent Protein Kinase Regulator Activity Regulation Of Biological Quality Regulation Of System Process CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of CAMP/PKA Signal Transduction Regulation Of Muscle System Process Response To Calcium Ion Protein Kinase A Catalytic Subunit Binding Regulation Of Multicellular Organismal Process Dendritic Spine Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Developmental Process Cellular Response To Metal Ion CAMP Binding Plasma Membrane System Process Glutamatergic Synapse Cellular Response To Actinomycin D Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Steroid Hormone Enzyme Binding Response To Toxic Substance Regulation Of Postsynaptic Membrane Potential Protein Domain Specific Binding Postsynaptic Membrane Response To Actinomycin D Extracellular Ligand-gated Monoatomic Ion Channel Activity Muscle System Process Cellular Response To UV-C Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Learning Or Memory Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ciliary Base Modulation Of Chemical Synaptic Transmission Transcription Factor AP-1 Complex Cellular Response To Histamine Response To Xenobiotic Stimulus
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