GABRB1 and NOD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GABRB1	NOD1
Description		gamma-aminobutyric acid type A receptor subunit beta1	nucleotide binding oligomerization domain containing 1
Image
GO Annotations	Cellular Component	Nuclear Envelope Plasma Membrane Membrane Dendrite Chloride Channel Complex Receptor Complex Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Chloride Channel Activity Ligand-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity GABA Receptor Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Ubiquitin Binding Protein-containing Complex Binding CARD Domain Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Response To Toxic Substance Central Nervous System Neuron Development Response To Progesterone Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Ovulation Cycle Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Autophagy Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Xenophagy Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Xenophagy
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide gamma-Hydroxybutyric acid Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Adventurousness ( 30643258) Cervical cancer ( 28806749) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA UBQLN1	15 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 CFTR GABRB1 IRGM NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		2560	10392
HPRD ID		15924	05815
Ensembl ID		ENSG00000163288	ENSG00000106100
Uniprot IDs		P18505 X5DNL6	A0A024RA73 G3XAL1 Q9Y239
PDB IDs		9CTV 9CXB 9CXD	2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Intracellular Signal Transduction Activation Of Immune Response GABA Receptor Binding Regulation Of Intracellular Signal Transduction Protein Kinase A Regulatory Subunit Binding Regulation Of Macroautophagy Positive Regulation Of Immune Response Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Signal Transduction Intracellular Signaling Cassette Adrenergic Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Autophagy Positive Regulation Of Immune System Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Localization To Membrane Regulation Of Innate Immune Response Kininogen Binding GABA-ergic Synapse Deoxyribonuclease Inhibitor Activity Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling T Cell Receptor Signaling Pathway Response To Butyrate Cellular Response To Hydrostatic Pressure Positive Regulation Of Endosome To Plasma Membrane Protein Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Response To Stress C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of MDA-5 Signaling Pathway Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Symmetric Synapse Endomembrane System Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitochondrial Ribosome Binding Cytosolic Ribosome Assembly Negative Regulation Of RIG-I Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Mitochondrial RNA Catabolic Process	Cell Death Apoptotic Process Programmed Cell Death CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Defense Response Cysteine-type Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway NLRP1 Inflammasome Complex Activation Of Innate Immune Response Regulation Of Innate Immune Response Pyroptotic Inflammatory Response Cysteine-type Peptidase Activity Response To Lipid Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Defense Response To Bacterium Response To Lipopolysaccharide Regulation Of Defense Response Positive Regulation Of Innate Immune Response Protein Maturation Canonical Inflammasome Complex Response To Molecule Of Bacterial Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Pyroptotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Stress Protein Processing Positive Regulation Of Interleukin-1 Production Response To Bacterium C-terminal Protein Lipidation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response Execution Phase Of Apoptosis Peptidase Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteolysis Protein Metabolic Process Regulation Of Interleukin-1 Production
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