PAN3 and SVIL

Number of citations of the paper that reports this interaction (PMID 20309963)
11

Data Source:
BioGRID (two hybrid)

		PAN3	SVIL
Gene Name		PAN3 poly(A) specific ribonuclease subunit	supervillin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytosol PAN Complex	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding ATP Binding Transferase Activity, Transferring Phosphorus-containing Groups Metal Ion Binding	Protein Binding Actin Filament Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Targeting Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS			Normalized brain volume ( 19010793)
Protein-Protein Interactions		3 interactors: PABPC1 PAN2 SVIL	37 interactors: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LIMA1 LMNA LMNB2 LUC7L2 MIF4GD MKL2 MPHOSPH9 NME2 NR3C1 ODF2 P2RX7 PAN3 PCNXL3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		255967	6840
HPRD ID		17818	04992
Ensembl ID		ENSG00000152520	ENSG00000197321
Uniprot IDs		Q58A45	O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Aromatic Compound Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process RNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process MRNA Stabilization MRNA Polyadenylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Polyadenylation Positive Regulation Of Cytokinesis Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Cytokinesis Gene Silencing By RNA Positive Regulation Of Translation Positive Regulation Of Type I Interferon Production Regulation Of MRNA Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Gene Silencing Regulation Of Type I Interferon Production RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Division Catabolic Process Skeletal Muscle Tissue Development Osteoblast Differentiation Skeletal Muscle Organ Development	Organelle Organization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Organelle Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Gene Expression Establishment Of Organelle Localization Apoptotic Process Transcription, DNA-templated Programmed Cell Death Regulation Of Signaling Microtubule-based Process Steroid Hormone Mediated Signaling Pathway Developmental Process Cell Death Death Establishment Of Localization In Cell RNA Biosynthetic Process Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Organelle Organization Transcription From RNA Polymerase II Promoter Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Organelle Localization Heterocycle Metabolic Process Establishment Of Protein Localization Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process
Tagcloud ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan2 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps	10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin
Tagcloud (Difference) ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan2 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps	10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin
Tagcloud (Intersection) ?