PAN3

Description		poly(A) specific ribonuclease subunit PAN3
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PAN Complex
	Molecular Function	Nucleotide Binding RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Poly(A) Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing Protein Targeting Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Pathways		Deadenylation of mRNA
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)
Novel Interacting Genes		3 novel interacting genes: GSX1 LNX2 MTIF3
Interacting Genes		5 interacting genes: PABPC1 PAN2 RNF10 SVIL TNRC6B
Entrez ID		255967
HPRD ID		17818
Ensembl ID		ENSG00000152520
Uniprot IDs		Q58A45
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process P-body PAN Complex Mitochondrial Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Catabolic Process Nucleic Acid Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Post-transcriptional Regulation Of Gene Expression MCRD-mediated MRNA Stability Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Microtubule Minus-end RNA Catabolic Process Negative Regulation Of Schwann Cell Proliferation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Adenohypophysis Development CRD-mediated MRNA Stabilization Spinal Cord Association Neuron Differentiation Poly(A)-specific Ribonuclease Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Actin Filament Severing Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hypothalamus Development
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