RICTOR and SGK1

Number of citations of the paper that reports this interaction (PubMedID 20832730)
51

Data Source:
BioGRID (enzymatic study)

		RICTOR	SGK1
Description		RPTOR independent companion of MTOR complex 2	serum/glucocorticoid regulated kinase 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane TORC2 Complex Serine/threonine Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Enzyme-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cytoskeleton Organization Lipid Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Establishment Of Cell Polarity	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs			Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB MTOR PLK1 SGK1 SIRT1 USP9X	38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC
Entrez ID		253260	6446
HPRD ID		10682	04264
Ensembl ID		ENSG00000164327	ENSG00000118515
Uniprot IDs		A0AA34QVX7 D6R9S6 Q6R327	B7Z325 E9PR89 O00141
PDB IDs		5ZCS 6ZWM 6ZWO 7PE7 7PE8 7PE9 7TZO	2R5T 3HDM 3HDN 7PUE
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Beta-catenin Destruction Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of TORC2 Signaling Protein Destabilization Regulation Of Cellular Response To Heat Protein Kinase Activity Cytoplasm Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process IkappaB Kinase Activity Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of TORC2 Signaling Regulation Of Glycogen (starch) Synthase Activity Regulation Of Organelle Assembly Proteasomal Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Proteolysis Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Complex Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-3 Cell Cycle Phase Transition Regulation Of Type B Pancreatic Cell Development	Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus
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