RICTOR and SIRT1

Number of citations of the paper that reports this interaction (PMID 22084251)
5

Data Source:
BioGRID (enzymatic study)

		RICTOR	SIRT1
Gene Name		RPTOR independent companion of MTOR, complex 2	sirtuin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol TORC2 Complex	Nuclear Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nuclear Euchromatin Nuclear Heterochromatin Nucleolus Cytoplasm Mitochondrion PML Body RDNA Heterochromatin ESC/E(Z) Complex
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding	Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Keratin Filament Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Actin Cytoskeleton Reorganization TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling	Single Strand Break Repair Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Adaptive Immune Response DNA Replication DNA Repair Chromatin Organization Chromatin Silencing Establishment Of Chromatin Silencing Maintenance Of Chromatin Silencing Methylation-dependent Chromatin Silencing Transcription, DNA-templated RRNA Processing Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To Starvation Gene Expression Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Protein Destabilization Positive Regulation Of Chromatin Silencing Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Response To Endoplasmic Reticulum Stress Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: AKT1 AKT1S1 CHUK CUL1 EIF4EBP1 GSK3B HDAC1 IKBKB ILK MTOR RPS6KB1 SGK1 SIRT1	47 interactors: AKT1 ARNTL BCL11A BHLHE41 CDK6 CSNK2B CTTN EP300 ESRRA FOS FOXO1 FOXO3 GAPDH HES1 HEY2 HIC1 HIST1H1B HIST1H3A HNF4A IRS2 MAPK8 MAPT MYCN NBN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARGC1A PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 SREBF1 STK11 STK4 TP53 UBE2I VDR
Entrez ID		253260	23411
HPRD ID		10682	08381
Ensembl ID		ENSG00000164327	ENSG00000096717
Uniprot IDs		Q6R327	A8K128 B0QZ35 E9PC49 Q96EB6
PDB IDs			4I5I
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Response To Heat Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Temperature Stimulus Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Response To Heat Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Fc Receptor Signaling Pathway Regulation Of Cell Size Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Cell Size Response To Organic Substance Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Immune Response Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death TOR Signaling Regulation Of Cell Cycle Regulation Of Cell Proliferation	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Cellular Response To Hormone Stimulus Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Intracellular Receptor Signaling Pathway System Development Response To Hormone Response To Organic Substance Regulation Of Signaling Developmental Process RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Signaling Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk	1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk	1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride
Tagcloud (Intersection) ?