RICTOR and EIF4EBP1

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		RICTOR	EIF4EBP1
Gene Name		RPTOR independent companion of MTOR, complex 2	eukaryotic translation initiation factor 4E binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol TORC2 Complex	Nucleoplasm Cytoplasm Cytosol Protein Complex
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Actin Cytoskeleton Reorganization TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Response To Ischemia Translation Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	IRS-mediated signalling mTOR signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Release of eIF4E Eukaryotic Translation Initiation PKB-mediated events Cap-dependent Translation Initiation PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Translation IRS-related events Release of eIF4E mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: AKT1 AKT1S1 CHUK CUL1 EIF4EBP1 GSK3B HDAC1 IKBKB ILK MTOR RPS6KB1 SGK1 SIRT1	32 interactors: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAP1 MAPKAPK5 MLST8 MTOR MVD PPP2CA PPP2R4 PRKCA PRKDC REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4
Entrez ID		253260	1978
HPRD ID		10682	03746
Ensembl ID		ENSG00000164327	ENSG00000187840
Uniprot IDs		Q6R327	Q13541
PDB IDs			1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Response To Heat Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Temperature Stimulus Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Response To Heat Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Fc Receptor Signaling Pathway Regulation Of Cell Size Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Cell Size Response To Organic Substance Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Immune Response Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death TOR Signaling Regulation Of Cell Cycle Regulation Of Cell Proliferation	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Cycle Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Cellular Protein Modification Process Regulation Of Protein Phosphorylation Cell Communication Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Protein Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Cell Death
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk	bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?		autophagy