SLC17A8 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		SLC17A8	DNAJC5
Description		solute carrier family 17 member 8	DnaJ heat shock protein family (Hsp40) member C5
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Glutamatergic Synapse Pericellular Basket	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Protein Binding Secondary Active Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity L-glutamate Uniporter Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	Neural Retina Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Sensory Perception Of Sound L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Regulation Of Acetylcholine Uptake L-glutamate Import Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Phosphate Ion Homeostasis Transmembrane Transport Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle Chloride Transmembrane Transport	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		SLC-mediated transport of neurotransmitters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Sensory processing of sound by inner hair cells of the cochlea	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		246213	80331
HPRD ID		10457	08539
Ensembl ID		ENSG00000179520	ENSG00000101152
Uniprot IDs		Q8NDX2	Q9H3Z4
PDB IDs			2N04 2N05
Enriched GO Terms of Interacting Partners?		Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Phylloquinone Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Leukotriene B4 Catabolic Process Vitamin K Catabolic Process Intracellular Membrane-bounded Organelle 20-hydroxy-leukotriene B4 Omega Oxidase Activity Vitamin E Metabolic Process Alkane 1-monooxygenase Activity Menaquinone Metabolic Process 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Transport Fatty Acid Omega-oxidation Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Menaquinone Catabolic Process ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Golgi Trans Cisterna Arachidonate Epoxygenase Activity Omega-hydroxylase P450 Pathway Intestinal Epithelial Cell Development Golgi Medial Cisterna Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin K Metabolic Process Epoxygenase P450 Pathway Regulation Of Synaptic Vesicle Cycle Columnar/cuboidal Epithelial Cell Development Positive Regulation Of Icosanoid Secretion Ketone Catabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Fatty Acid Transport Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Protein Heterooligomerization Multicellular Organismal-level Water Homeostasis Leukotriene Metabolic Process Regulation Of Fatty Acid Transport Synaptic Vesicle Exocytosis Very Long-chain Fatty Acid Metabolic Process Sodium Ion Homeostasis COPII-coated ER To Golgi Transport Vesicle Negative Regulation Of Lipid Transport Arachidonate Metabolic Process	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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