SLC17A8 and TMEM120B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC17A8	TMEM120B
Description		solute carrier family 17 member 8	transmembrane protein 120B
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Glutamatergic Synapse Pericellular Basket	Nucleus Nuclear Inner Membrane Membrane
	Molecular Function	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Protein Binding Secondary Active Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity L-glutamate Uniporter Activity	Monoatomic Ion Channel Activity Protein Binding
	Biological Process	Neural Retina Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Sensory Perception Of Sound L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Regulation Of Acetylcholine Uptake L-glutamate Import Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Phosphate Ion Homeostasis Transmembrane Transport Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle Chloride Transmembrane Transport	Fat Cell Differentiation Protein Heterooligomerization
Pathways		SLC-mediated transport of neurotransmitters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)	HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 27863252 32888494) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6	59 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 ARL13B BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 HSD17B13 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 SLC35H1 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		246213	144404
HPRD ID		10457	19119
Ensembl ID		ENSG00000179520	ENSG00000188735
Uniprot IDs		Q8NDX2	A0PK00
PDB IDs			7F73
Enriched GO Terms of Interacting Partners?		Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Phylloquinone Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Leukotriene B4 Catabolic Process Vitamin K Catabolic Process Intracellular Membrane-bounded Organelle 20-hydroxy-leukotriene B4 Omega Oxidase Activity Vitamin E Metabolic Process Alkane 1-monooxygenase Activity Menaquinone Metabolic Process 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Transport Fatty Acid Omega-oxidation Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Menaquinone Catabolic Process ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Golgi Trans Cisterna Arachidonate Epoxygenase Activity Omega-hydroxylase P450 Pathway Intestinal Epithelial Cell Development Golgi Medial Cisterna Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin K Metabolic Process Epoxygenase P450 Pathway Regulation Of Synaptic Vesicle Cycle Columnar/cuboidal Epithelial Cell Development Positive Regulation Of Icosanoid Secretion Ketone Catabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Fatty Acid Transport Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Protein Heterooligomerization Multicellular Organismal-level Water Homeostasis Leukotriene Metabolic Process Regulation Of Fatty Acid Transport Synaptic Vesicle Exocytosis Very Long-chain Fatty Acid Metabolic Process Sodium Ion Homeostasis COPII-coated ER To Golgi Transport Vesicle Negative Regulation Of Lipid Transport Arachidonate Metabolic Process	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Organic Hydroxy Compound Transport Steroid Dehydrogenase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Transmembrane Transport Monoamine Transport Leukocyte Mediated Immunity Gamma-aminobutyric Acid Biosynthetic Process Prostanoid Metabolic Process Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Transport Norepinephrine Transport Gamma-aminobutyric Acid Metabolic Process Icosanoid Metabolic Process Ammonium Channel Activity Neurotransmitter Transport Symporter Activity Icosanoid Biosynthetic Process Ammonium Transmembrane Transport Cellular Response To Cocaine Cellular Detoxification Negative Regulation Of Peptide Secretion Amine Transport Cytokine Receptor Activity Serotonin Transport L-glutamate Transmembrane Transporter Activity Lymphocyte Mediated Immunity Non-motile Cilium Assembly Nuclear Envelope Water Channel Activity Negative Regulation Of Leukocyte Apoptotic Process
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