SLC17A8

Description		solute carrier family 17 member 8
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Glutamatergic Synapse Pericellular Basket
	Molecular Function	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Protein Binding Secondary Active Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity L-glutamate Uniporter Activity
	Biological Process	Neural Retina Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Sensory Perception Of Sound L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Regulation Of Acetylcholine Uptake L-glutamate Import Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Phosphate Ion Homeostasis Transmembrane Transport Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle Chloride Transmembrane Transport
Pathways		SLC-mediated transport of neurotransmitters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6
Entrez ID		246213
HPRD ID		10457
Ensembl ID		ENSG00000179520
Uniprot IDs		Q8NDX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Phylloquinone Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Leukotriene B4 Catabolic Process Vitamin K Catabolic Process Intracellular Membrane-bounded Organelle 20-hydroxy-leukotriene B4 Omega Oxidase Activity Vitamin E Metabolic Process Alkane 1-monooxygenase Activity Menaquinone Metabolic Process 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Transport Fatty Acid Omega-oxidation Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Menaquinone Catabolic Process ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Golgi Trans Cisterna Arachidonate Epoxygenase Activity Omega-hydroxylase P450 Pathway Intestinal Epithelial Cell Development Golgi Medial Cisterna Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin K Metabolic Process Epoxygenase P450 Pathway Regulation Of Synaptic Vesicle Cycle Columnar/cuboidal Epithelial Cell Development Positive Regulation Of Icosanoid Secretion Ketone Catabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Fatty Acid Transport Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Protein Heterooligomerization Multicellular Organismal-level Water Homeostasis Leukotriene Metabolic Process Regulation Of Fatty Acid Transport Synaptic Vesicle Exocytosis Very Long-chain Fatty Acid Metabolic Process Sodium Ion Homeostasis COPII-coated ER To Golgi Transport Vesicle Negative Regulation Of Lipid Transport Arachidonate Metabolic Process
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