SLC17A8 and YIPF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC17A8	YIPF6
Description		solute carrier family 17 member 8	Yip1 domain family member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Glutamatergic Synapse Pericellular Basket	Golgi Trans Cisterna Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Trans-Golgi Network Endomembrane System Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Protein Binding Secondary Active Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity L-glutamate Uniporter Activity	Protein Binding Identical Protein Binding
	Biological Process	Neural Retina Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Sensory Perception Of Sound L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Regulation Of Acetylcholine Uptake L-glutamate Import Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Phosphate Ion Homeostasis Transmembrane Transport Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle Chloride Transmembrane Transport	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intestinal Epithelial Cell Development
Pathways		SLC-mediated transport of neurotransmitters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Sensory processing of sound by inner hair cells of the cochlea	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)	Male-pattern baldness ( 28196072)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6	93 interacting genes: APOL2 AQP2 AQP6 ARL13B ATP6V0E1 CD79A CGRRF1 CISD2 CLN8 CNR2 CPLX4 CRB3 CREB3L1 CREB3L3 CXorf66 CYSLTR2 EBP EFNA5 ELOVL4 ERGIC3 F2RL1 FAM209A FCER1G FFAR2 FKBP7 GJA5 GJA8 GJB1 GPR101 GPR152 GPR42 GPX8 HSD17B11 IL10RA IL1RL1 IL27RA JKAMP KCNJ6 KCNK5 LMNA LRRC25 LRRC3B LRRC4C LY6G6C LYVE1 MMD MS4A3 MTIF3 MUC1 NDUFAF1 ODF4 PDZK1IP1 PSCA RAET1L REEP4 RETREG3 RHCG RNF185 SCN3B SLC10A1 SLC10A6 SLC12A7 SLC17A8 SLC18A1 SLC30A4 SLC30A8 SLC35H1 SLC38A7 SLC39A1 SLC39A2 SLC61A1 SLC71A2 SLC7A14 SLC7A8 SSMEM1 STOM TCTA THAP4 TMEM106C TMEM11 TMEM130 TMEM14B TMEM237 TMEM31 TMEM52B TMEM71 TMX2 TRARG1 TRHR TVP23B ULBP2 YIPF1 YIPF2
Entrez ID		246213	286451
HPRD ID		10457	06639
Ensembl ID		ENSG00000179520	ENSG00000181704
Uniprot IDs		Q8NDX2	Q96EC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Phylloquinone Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Leukotriene B4 Catabolic Process Vitamin K Catabolic Process Intracellular Membrane-bounded Organelle 20-hydroxy-leukotriene B4 Omega Oxidase Activity Vitamin E Metabolic Process Alkane 1-monooxygenase Activity Menaquinone Metabolic Process 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Transport Fatty Acid Omega-oxidation Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Menaquinone Catabolic Process ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Golgi Trans Cisterna Arachidonate Epoxygenase Activity Omega-hydroxylase P450 Pathway Intestinal Epithelial Cell Development Golgi Medial Cisterna Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin K Metabolic Process Epoxygenase P450 Pathway Regulation Of Synaptic Vesicle Cycle Columnar/cuboidal Epithelial Cell Development Positive Regulation Of Icosanoid Secretion Ketone Catabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Fatty Acid Transport Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Protein Heterooligomerization Multicellular Organismal-level Water Homeostasis Leukotriene Metabolic Process Regulation Of Fatty Acid Transport Synaptic Vesicle Exocytosis Very Long-chain Fatty Acid Metabolic Process Sodium Ion Homeostasis COPII-coated ER To Golgi Transport Vesicle Negative Regulation Of Lipid Transport Arachidonate Metabolic Process	Membrane Transmembrane Transport Plasma Membrane Protein Binding Endoplasmic Reticulum Monoatomic Ion Transport Zinc Ion Transmembrane Transporter Activity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Inorganic Ion Transmembrane Transport Regulation Of Renin Secretion Into Blood Stream Amino Acid Transmembrane Transport Connexin Complex Import Across Plasma Membrane Gap Junction Channel Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Positive Regulation Of Acute Inflammatory Response Gap Junction Transmembrane Transporter Activity SA Node Cell Action Potential Side Of Membrane Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Monoatomic Cation Transmembrane Transport Neurotransmitter Loading Into Synaptic Vesicle Renal Water Transport Monoatomic Ion Transmembrane Transport Gap Junction Assembly Golgi Trans Cisterna Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity G Protein-coupled Receptor Activity Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Golgi Medial Cisterna
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