WAC and TRAF3IP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		WAC	TRAF3IP1
Description		WW domain containing adaptor with coiled-coil	TRAF3 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)	Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17	31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC
Entrez ID		51322	26146
HPRD ID		18291	09571
Ensembl ID		ENSG00000095787	ENSG00000204104
Uniprot IDs		Q9BTA9	Q8TDR0
PDB IDs			2EQO 8KCQ
Enriched GO Terms of Interacting Partners?		Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium	Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation
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