WAC and CRKL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WAC	CRKL
Gene Name		WW domain containing adaptor with coiled-coil	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Binding Chromatin Binding Protein Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Histone Monoubiquitination Positive Regulation Of Macroautophagy Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process G1 DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Histone H2B Conserved C-terminal Lysine Ubiquitination	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways			Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: AKAP9 APP CRKL CTD DYDC1 KLC3 KRT15 LNX1 MTUS2 NDE1 NFE2L2 POLR2A RNF20 RNF40 SYTL5 TRAF1 TRAF3IP1 TRAF3IP3 UBQLN4 VCP VCPIP1 ZDHHC17	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		51322	1399
HPRD ID		18291	03596
Ensembl ID		ENSG00000095787	ENSG00000099942
Uniprot IDs		Q9BTA9	P46109
PDB IDs			2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Microtubule-based Transport Protein Ubiquitination Cytoskeleton-dependent Intracellular Transport Protein Modification By Small Protein Conjugation Histone H2B Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Microtubule-based Movement Histone Monoubiquitination Cellular Component Assembly Histone Ubiquitination Cellular Macromolecule Catabolic Process Protein Monoubiquitination Intracellular Transport Proteolysis Axon Cargo Transport Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Synaptic Growth At Neuromuscular Junction Endoplasmic Reticulum Membrane Fusion Transcription, RNA-templated Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Microtubule-based Process Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Cellular Response To Unfolded Protein Establishment Of Localization In Cell ER-nucleus Signaling Pathway Proteasomal Ubiquitin-independent Protein Catabolic Process Golgi Reassembly Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Topologically Incorrect Protein Regulation Of Embryonic Development G2/M Transition Of Mitotic Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Response To Unfolded Protein Regulation Of Protein Deubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?		bd ccrd composite cooking defatted equation fitted flour gruel gsl ingredient moisture noodle noodles polynomial proximate quadratic rotatable salted sc soy swelling tapioca ve wheat wur x1 x2 x3	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?		bd ccrd composite cooking defatted equation fitted flour gruel gsl ingredient moisture noodle noodles polynomial proximate quadratic rotatable salted sc soy swelling tapioca ve wheat wur x1 x2 x3	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?