WAC and CCDC6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WAC	CCDC6
Description		WW domain containing adaptor with coiled-coil	coiled-coil domain containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Cytoplasm Cytosol Cytoskeleton
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Identical Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling	Cytoskeleton Organization
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Thyroid cancer
GWAS		Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)	Alopecia areata ( 25608926) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17	31 interacting genes: ATF2 ATF5 CCDC136 CCDC33 CREB1 CSNK2A1 CYTH4 DRC4 DSCR9 FBXW7 LHX3 LRSAM1 LUZP4 MAPK3 MAPK7 MEOX2 PAX6 PIN1 PPP4C SH3RF1 SNAPC1 SORBS3 TFIP11 TRIM14 UBE2I WAC ZNF250 ZNF354C ZNF620 ZNF774 ZNF835
Entrez ID		51322	8030
HPRD ID		18291	09064
Ensembl ID		ENSG00000095787	ENSG00000108091
Uniprot IDs		Q9BTA9	Q05CP8 Q16204
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nucleus Phosphothreonine Residue Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Pituitary Gland Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process MAPK Cascade Transcription Coregulator Binding Protein Stabilization Positive Regulation Of Xenophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gland Development Negative Regulation Of Proteolysis Signal Transduction In Response To DNA Damage DNA Binding CAMP Response Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Autophagy MAP Kinase Activity Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Damage Response Positive Regulation Of Catabolic Process Positive Regulation Of Macromolecule Metabolic Process
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