LCN1 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCN1	RECK
Description		lipocalin 1	reversion inducing cysteine rich protein with kazal motifs
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Chloride Ion Binding Small Molecule Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Sensory Perception Of Taste	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		Transport of fatty acids	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Tretinoin
Diseases
GWAS		Subcutaneous adipose tissue ( 29178545) Subcutaneous adipose tissue (sex interaction) ( 29178545)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		9 interacting genes: ALOX5 FAM25A FAM25C FAM25G LMBR1L LTF LYZ RECK UBQLN2	43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		3933	8434
HPRD ID		01059	05567
Ensembl ID		ENSG00000160349	ENSG00000122707
Uniprot IDs		P31025	A8K9D8 O95980 Q6P9E2
PDB IDs		1XKI 3EYC 4QAF 5T43	8TZP
Enriched GO Terms of Interacting Partners?		Leukotriene A4 Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Regulation Of Bone Mineralization Arachidonate 5-lipoxygenase Activity Humoral Immune Response Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Specific Granule Lumen Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Tertiary Granule Lumen Defense Response To Gram-negative Bacterium Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Ossification Arachidonate Metabolite Production Involved In Inflammatory Response Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Phagocytic Vesicle Lumen Defense Response To Gram-positive Bacterium Positive Regulation Of Bone Mineralization Involved In Bone Maturation Killing Of Cells Of Another Organism Membrane Destabilizing Activity Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Negative Regulation Of Osteoclast Development Antimicrobial Humoral Response Negative Regulation Of Vascular Wound Healing Lysozyme Activity Blood Vessel Maturation Leukocyte Chemotaxis Involved In Inflammatory Response Cell Killing Positive Regulation Of Chondrocyte Proliferation Regulation Of Osteoclast Development	Keratin Filament Intermediate Filament
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