MAFF and HDAC5

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MAFF	HDAC5
Gene Name		v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	histone deacetylase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Parturition Blood Coagulation Skeletal Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		23 interactors: ATF3 BACH1 BACH2 BATF2 BATF3 DDIT3 FOS GTF2A1L HDAC5 HOXD12 MAFG MAFIP NFE2 NFE2L1 NFE2L2 NFE2L3 NFIL3 NR3C1 NRF1 OVOL1 PPARG PRRX1 PSAP	59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		23764	10014
HPRD ID		05343	09246
Ensembl ID		ENSG00000185022	ENSG00000108840
Uniprot IDs		Q9ULX9	Q9UQL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development System Development Anatomical Structure Development Organ Development Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Response To Stress Myeloid Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Hemopoiesis Cellular Response To Oxidative Stress Cellular Response To Organic Substance Immune System Development	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation
Tagcloud ?		albeit arrested asymmetric constitute dimerizes dissect e2 erythroid heterodimeric lineages livers mafg mafk megakaryocyte megakaryocytes megakaryocytic mpl nucleotides outside p18 p45 polypeptides predominate profound rarity readily recognizes thrombocytopenia	125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis
Tagcloud (Difference) ?		albeit arrested asymmetric constitute dimerizes dissect e2 erythroid heterodimeric lineages livers mafg mafk megakaryocyte megakaryocytes megakaryocytic mpl nucleotides outside p18 p45 polypeptides predominate profound rarity readily recognizes thrombocytopenia	125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis
Tagcloud (Intersection) ?