MAFF and OVOL1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MAFF	OVOL1
Name		MAF bZIP transcription factor F	ovo like transcriptional repressor 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion RNA Polymerase II Transcription Regulator Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Parturition Skeletal Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Spermatogenesis Mesoderm Development Epidermis Development Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Proliferation Skin Development Keratinocyte Proliferation Meiotic Cell Cycle Phase Transition Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Stem Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Proliferation
Pathways		Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Birth weight ( 31043758 ) Estimated glomerular filtration rate ( 31451708 31152163 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting plasma glucose ( 32902719 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglyceride levels ( 32154731 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 )	A body shape index ( 34021172 ) Acne (severe) ( 30542056 24927181 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic sensitization ( 30013184 ) Apolipoprotein A1 levels ( 32203549 ) Asthma ( 31361310 30929738 31619474 32296059 34103634 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Atopic dermatitis ( 22197932 23042114 26482879 ) Atopic march ( 26542096 ) Basal cell carcinoma ( 33549134 ) Blond vs. brown/black hair color ( 30531825 ) Breast cancer ( 23535729 ) Chronic kidney disease ( 20383146 ) DNA methylation (variation) ( 23725790 ) Eczema ( 31361310 ) Estimated glomerular filtration rate ( 31451708 ) High density lipoprotein cholesterol levels ( 31928498 ) Hip circumference adjusted for BMI ( 34021172 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 33710309 ) Medication use (diuretics) ( 31015401 ) Rosacea symptom severity ( 29771307 ) Serum uric acid levels ( 30993211 ) Systemic lupus erythematosus ( 33272962 26502338 28714469 ) Systolic blood pressure ( 31928498 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Urate levels ( 23263486 ) Waist circumference ( 31928498 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		20 interacting genes: ATF3 BACH2 BATF2 BATF3 DDIT3 FOS GTF2A1L HDAC5 HOXD12 MAFIP NFE2 NFE2L1 NFE2L2 NFIL3 NR3C1 NRF1 OVOL1 PPARG PRRX1 PSAP	3 interacting genes: FAM90A1 LMNB2 MAFF
Entrez ID		23764	5017
HPRD ID		05343	09080
Ensembl ID		ENSG00000185022	ENSG00000172818
Uniprot IDs		Q9ULX9	G3V1B0 O14753
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding Chromatin Integrated Stress Response Signaling DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mononuclear Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Protein-DNA Complex Leukocyte Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Myeloid Cell Differentiation Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II Myeloid Leukocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process CHOP-ATF3 Complex Positive Regulation Of Biosynthetic Process Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cell Redox Homeostasis Transcription Coregulator Binding Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Metabolic Process	None