GSPT2 and UPF1

Number of citations of the paper that reports this interaction (PMID 18447585)
69

Data Source:
BioGRID (pull down)

		GSPT2	UPF1
Gene Name		G1 to S phase transition 2	UPF1 regulator of nonsense transcripts homolog (yeast)
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Gene Ontology Annotations	Cellular Component	Cytosol	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Cell Cycle Gene Expression Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Translation Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP ETF1 GSPT1 PABPC1 UPF1	31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		23708	5976
HPRD ID		02334	03254
Ensembl ID		ENSG00000189369	ENSG00000005007
Uniprot IDs		Q8IYD1	Q92900
PDB IDs		3KUJ	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Termination Cellular Macromolecule Catabolic Process MRNA Polyadenylation RNA Polyadenylation RNA Metabolic Process Gene Expression MRNA 3'-end Processing Catabolic Process RNA 3'-end Processing Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Disassembly Nucleobase-containing Compound Metabolic Process Translational Termination Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Nitrogen Compound Metabolic Process Protein Methylation Cellular Protein Complex Disassembly Collateral Sprouting In Absence Of Injury Nitrogen Compound Metabolic Process Protein Complex Disassembly Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Histone MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Dosage Compensation By Inactivation Of X Chromosome Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Dosage Compensation Methylation MRNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Cellular Copper Ion Homeostasis	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing
Tagcloud ?			aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Difference) ?			aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Intersection) ?