GSPT2 and GSPT1

Number of citations of the paper that reports this interaction (PubMedID 9712840)
0

Data Source:
HPRD (two hybrid, in vivo)

		GSPT2	GSPT1
Description		G1 to S phase transition 2	G1 to S phase transition 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex	Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS			Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		4 interacting genes: APP ETF1 GSPT1 PABPC1	13 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CEBPA CRBN ETF1 GSPT2 HINFP PABPC1 PIK3R1 USP15 XIAP
Entrez ID		23708	2935
HPRD ID		02334	00753
Ensembl ID		ENSG00000189369	ENSG00000103342
Uniprot IDs		Q8IYD1	B2RCT6 P15170 Q7KZX8
PDB IDs		3KUJ	3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT 6XK9
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Complex Regulation Of Translation Translation Release Factor Activity Nuclear-transcribed MRNA Catabolic Process Regulation Of Translational Termination Post-transcriptional Regulation Of Gene Expression MRNA Catabolic Process Translational Termination RNA Catabolic Process Negative Regulation Of Gene Expression Protein Methylation Nucleobase-containing Compound Catabolic Process Ribosome Disassembly Regulation Of Protein Metabolic Process Organelle Disassembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosolic Ribosome Translation Termination Factor Activity Cytoplasmic Translational Termination MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Methylation Negative Regulation Of Biosynthetic Process Regulation Of Protein-containing Complex Disassembly Protein-containing Complex Disassembly Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Macromolecule Metabolic Process PTB Domain Binding Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Translation Release Factor Activity, Codon Specific Methylation Macromolecule Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of RIG-I Signaling Pathway RNA Metabolic Process Translation Release Factor Complex Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Activity Regulation Of Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Canonical NF-kappaB Signal Transduction DNA-templated Transcription Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleic Acid Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Translational Termination Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Signal Transduction Nucleus Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Immune System Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Hemopoiesis Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Necrotic Cell Death Cytosol MRNA Catabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Poly(U) RNA Binding Positive Regulation Of Protein Modification Process Positive Regulation Of RNA Metabolic Process
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