GSPT2 and ETF1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		GSPT2	ETF1
Description		G1 to S phase transition 2	eukaryotic translation termination factor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex	Nucleus Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	RNA Binding Translation Release Factor Activity Peptidyl-tRNA Hydrolase Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		4 interacting genes: APP ETF1 GSPT1 PABPC1	8 interacting genes: CEBPA GSPT1 GSPT2 KEAP1 LIG4 OGT PPP2CA UBC
Entrez ID		23708	2107
HPRD ID		02334	02616
Ensembl ID		ENSG00000189369	ENSG00000120705
Uniprot IDs		Q8IYD1	B7Z7P8 P62495
PDB IDs		3KUJ	1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME 8SCB
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Complex Regulation Of Translation Translation Release Factor Activity Nuclear-transcribed MRNA Catabolic Process Regulation Of Translational Termination Post-transcriptional Regulation Of Gene Expression MRNA Catabolic Process Translational Termination RNA Catabolic Process Negative Regulation Of Gene Expression Protein Methylation Nucleobase-containing Compound Catabolic Process Ribosome Disassembly Regulation Of Protein Metabolic Process Organelle Disassembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosolic Ribosome Translation Termination Factor Activity Cytoplasmic Translational Termination MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Methylation Negative Regulation Of Biosynthetic Process Regulation Of Protein-containing Complex Disassembly Protein-containing Complex Disassembly Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Macromolecule Metabolic Process PTB Domain Binding Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Translation Release Factor Activity, Codon Specific Methylation Macromolecule Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Translation Release Factor Complex Translation Release Factor Activity Stem Cell Proliferation Translational Termination Cellular Response To Lithium Ion Macromolecule Catabolic Process Response To Lithium Ion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Embryonic Placenta Development Macromolecule Metabolic Process In Utero Embryonic Development Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Granulocyte Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Macrophage Differentiation Negative Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Response To Fluid Shear Stress Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Modification Process Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Establishment Of Integrated Proviral Latency Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Granzyme-mediated Apoptotic Signaling Pathway Chordate Embryonic Development Multicellular Organism Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Establishment Of Viral Latency Regulation Of ATP Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cell Population Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mononuclear Cell Differentiation Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process
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