GSPT2 and PABPC1

Number of citations: 0 (PubMedID 10358005)
Data Source: HPRD (two hybrid, in vitro)

		GSPT2	PABPC1
Name		G1 to S phase transition 2	poly(A) binding protein cytoplasmic 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		4 interacting genes: APP ETF1 GSPT1 PABPC1	55 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 MAPKAPK2 MKRN1 NDRG1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG
Entrez ID		23708	26986
HPRD ID		02334	05247
Ensembl ID		ENSG00000189369	ENSG00000070756
Uniprot IDs		Q8IYD1	P11940
PDB IDs		3KUJ	1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO
GO Terms Enriched among Interactors		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Complex Regulation Of Translation Translation Release Factor Activity Nuclear-transcribed MRNA Catabolic Process Regulation Of Translational Termination Post-transcriptional Regulation Of Gene Expression MRNA Catabolic Process Translational Termination RNA Catabolic Process Negative Regulation Of Gene Expression Protein Methylation Nucleobase-containing Compound Catabolic Process Ribosome Disassembly Regulation Of Protein Metabolic Process Organelle Disassembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosolic Ribosome Translation Termination Factor Activity Cytoplasmic Translational Termination MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Methylation Negative Regulation Of Biosynthetic Process Regulation Of Protein-containing Complex Disassembly Protein-containing Complex Disassembly Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Macromolecule Metabolic Process PTB Domain Binding Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Translation Release Factor Activity, Codon Specific Methylation Macromolecule Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly