GSPT2

Description		G1 to S phase transition 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Translation Release Factor Complex
	Molecular Function	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: APP ETF1 GSPT1 PABPC1
Entrez ID		23708
HPRD ID		02334
Ensembl ID		ENSG00000189369
Uniprot IDs		Q8IYD1
PDB IDs		3KUJ
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Complex Regulation Of Translation Translation Release Factor Activity Nuclear-transcribed MRNA Catabolic Process Regulation Of Translational Termination Post-transcriptional Regulation Of Gene Expression MRNA Catabolic Process Translational Termination RNA Catabolic Process Negative Regulation Of Gene Expression Protein Methylation Nucleobase-containing Compound Catabolic Process Ribosome Disassembly Regulation Of Protein Metabolic Process Organelle Disassembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosolic Ribosome Translation Termination Factor Activity Cytoplasmic Translational Termination MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Methylation Negative Regulation Of Biosynthetic Process Regulation Of Protein-containing Complex Disassembly Protein-containing Complex Disassembly Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Macromolecule Metabolic Process PTB Domain Binding Negative Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Translation Release Factor Activity, Codon Specific Methylation Macromolecule Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus
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