PABPC1 and DCAF13

		PABPC1	DCAF13
Description		poly(A) binding protein cytoplasmic 1	DDB1 and CUL4 associated factor 13
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Centrosome Cytosol Cell Junction Small-subunit Processome Cul4-RING E3 Ubiquitin Ligase Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	RNA Binding Protein Binding Nuclear Estrogen Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Oocyte Growth RRNA Processing Spindle Assembly Involved In Female Meiosis Female Gamete Generation Protein Ubiquitination Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Decidualization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Neddylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		55 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 MAPKAPK2 MKRN1 NDRG1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG	4 interacting genes: PTEN TK1 USP2-AS1 WARS1
Entrez ID		26986	25879
HPRD ID		05247	08528
Ensembl ID		ENSG00000070756	ENSG00000164934
Uniprot IDs		P11940	A0A087WT20 Q9NV06
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process MCRD-mediated MRNA Stability Complex Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Thymidine Metabolic Process Kinase Inhibitor Activity Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Pyrimidine Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
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