PABPC1 and LRP1B

		PABPC1	LRP1B
Description		poly(A) binding protein cytoplasmic 1	LDL receptor related protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation	Endocytosis Receptor-mediated Endocytosis Protein Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Aging ( 19367585) Asthma (childhood onset) ( 27611488) Asthma and eczema ( 34155719) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 25673413 20935630 28892062) Body size at age 10 ( 32376654) Cataracts ( 34127677) Cerebellum white matter volume ( 31530798) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive performance (processing speed) ( 31598132) Congenital heart disease (inherited effect) ( 28468790) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dietary fat liking ( 32516399) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31217584) Facial attractiveness (male raters) ( 30946739) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepcidin/ferritin ratio ( 27846281) Household income (MTAG) ( 31844048) Influenza A (H1N1) infection ( 26379185) Keratoconus ( 33649486) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 21102462 25231870) Mood instability ( 31168069) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Optic nerve measurement (disc area) ( 20395239) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Periodontitis (CDC/AAP) ( 24024966) Post bronchodilator FEV1 ( 26634245) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185) Type 1 diabetes ( 32005708) Type 2 diabetes ( 30130595)
Interacting Genes		55 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 MAPKAPK2 MKRN1 NDRG1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG	8 interacting genes: APP DYRK1A FGA LCOR LRPAP1 PLAT PLAUR SERPINE1
Entrez ID		26986	53353
HPRD ID		05247	16383
Ensembl ID		ENSG00000070756	ENSG00000168702
Uniprot IDs		P11940	Q9NZR2
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO
Enriched GO Terms of Interacting Partners?		Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	Signaling Receptor Binding Regulation Of Hemostasis Regulation Of Protein Maturation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Fibrinolysis Negative Regulation Of Protein Maturation Regulation Of Wound Healing Regulation Of Response To Wounding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Serine Protease Inhibitor Complex Regulation Of Protein Metabolic Process Regulation Of Protein Processing Platelet Alpha Granule Lumen Negative Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Negative Regulation Of Gene Expression Regulation Of Body Fluid Levels Cell Surface Negative Regulation Of Multicellular Organismal Process Plasminogen Activation Negative Regulation Of Fibrinolysis Blood Coagulation Coagulation Hemostasis Regulation Of Receptor-mediated Endocytosis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Platelet Alpha Granule Regulation Of Apoptotic Signaling Pathway Regulation Of Amyloid-beta Clearance Negative Regulation Of Biosynthetic Process Negative Regulation Of Signaling Endosome Lumen Negative Regulation Of Cell Communication Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Blood Coagulation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Coagulation Regulation Of Biological Quality Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Monocyte Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process
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