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NHP2L1 and CHST1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
NHP2L1
CHST1
Gene Name
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Box C/D SnoRNP Complex
Protein Complex
Golgi Membrane
Integral Component Of Membrane
Molecular Function
RNA Binding
Protein Binding
SnoRNA Binding
Poly(A) RNA Binding
Sulfotransferase Activity
Keratan Sulfotransferase Activity
Biological Process
MRNA Splicing, Via Spliceosome
RNA Splicing
Gene Expression
Ribosome Biogenesis
Carbohydrate Metabolic Process
Polysaccharide Metabolic Process
Galactose Metabolic Process
Sulfur Compound Metabolic Process
Inflammatory Response
Pathogenesis
Keratan Sulfate Biosynthetic Process
Glycosaminoglycan Metabolic Process
Keratan Sulfate Metabolic Process
Small Molecule Metabolic Process
Pathways
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Defective B4GALT7 causes EDS, progeroid type
MPS I - Hurler syndrome
Keratan sulfate/keratin metabolism
MPS IX - Natowicz syndrome
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST14 causes EDS, musculocontractural type
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
Glycogen storage diseases
Defective CHST6 causes MCDC1
MPS IIID - Sanfilippo syndrome D
MPS IIIC - Sanfilippo syndrome C
Keratan sulfate biosynthesis
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
MPS IV - Morquio syndrome A
MPS IV - Morquio syndrome B
Defective CHSY1 causes TPBS
Metabolism of carbohydrates
MPS VII - Sly syndrome
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
CDKN2C
CHST1
GTF3C1
LRIF1
MAP1LC3B
POLA2
PPIH
PRPF3
PRPF31
PRPF4
RAD17
RBM10
SNW1
XRCC6
2 interactors:
NHP2L1
SFN
Entrez ID
4809
8534
HPRD ID
03197
07051
Ensembl ID
ENSG00000100138
Uniprot IDs
P55769
Q6FHM6
O43916
PDB IDs
1E7K
2JNB
2OZB
3SIU
3SIV
Enriched GO Terms of Interacting Partners
?
RNA Splicing
MRNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
MRNA Metabolic Process
RNA Processing
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Spliceosomal Tri-snRNP Complex Assembly
RNA Metabolic Process
Gene Expression
Cellular Metabolic Process
Spliceosomal SnRNP Assembly
Positive Regulation Of Viral Process
Telomere Maintenance
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Hyperosmotic Salinity Response
Macromolecule Biosynthetic Process
5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter
TRNA Transcription From RNA Polymerase III Promoter
Cellular Response To X-ray
Regulation Of Vitamin D Receptor Signaling Pathway
Regulation Of Viral Process
G1/S Transition Of Mitotic Cell Cycle
TRNA Transcription
Ribonucleoprotein Complex Assembly
Establishment Of Integrated Proviral Latency
Metabolic Process
Cellular Hyperosmotic Response
Hyperosmotic Salinity Response
Establishment Of Viral Latency
Positive Regulation By Host Of Viral Transcription
Mitotic Cell Cycle Process
DNA Replication Checkpoint
Cellular Response To Salt Stress
DNA Recombination
Mitotic Cell Cycle
DNA Ligation
Regulation Of Epidermal Cell Division
Keratinocyte Development
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Protein Export From Nucleus
Establishment Of Skin Barrier
Regulation Of Water Loss Via Skin
Positive Regulation Of Epidermal Cell Differentiation
Regulation Of Keratinocyte Proliferation
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Regulation Of Protein Export From Nucleus
Release Of Cytochrome C From Mitochondria
Positive Regulation Of Epidermis Development
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Epidermal Cell Differentiation
Keratinization
Multicellular Organismal Water Homeostasis
Positive Regulation Of Mitochondrion Organization
Water Homeostasis
Regulation Of Epidermis Development
Apoptotic Mitochondrial Changes
Positive Regulation Of Epithelial Cell Differentiation
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Keratinocyte Differentiation
Regulation Of Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
RNA Phosphodiester Bond Hydrolysis
Positive Regulation Of Nucleocytoplasmic Transport
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