ARL1 and GOLGA4

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (x-ray crystallography, pull down, two hybrid, proximity labelling technology)
HPRD (in vivo, two hybrid, in vitro)

		ARL1	GOLGA4
Description		ARF like GTPase 1	golgin A4
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Activator Activity Protein Domain Specific Binding Metal Ion Binding Phospholipase D Activator Activity	Protein Binding Small GTPase Binding GTPase Binding
	Biological Process	Intracellular Protein Transport Golgi Organization Toxin Metabolic Process Vesicle-mediated Transport Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi	Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Golgi Vesicle Transport
Pathways		Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Lung cancer in never smokers ( 28604730) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30578418) Subjective response to lithium treatment ( 26503763)
Interacting Genes		8 interacting genes: ARFIP2 COPG2 DRD2 GCC1 GCC2 GOLGA1 GOLGA4 SCOC	11 interacting genes: APP ARL1 ARL3 CIP2A EIF4ENIF1 MACF1 RAB6A RNF10 SERPINB5 TNIK TRAF3IP1
Entrez ID		400	2803
HPRD ID		04574	03941
Ensembl ID		ENSG00000120805	ENSG00000144674
Uniprot IDs		B4DZG7 P40616	A0A8V8TPI8 A0A8V8TQI6 A0A9L9PX25 C9J0Y3 H0Y6I0 Q13439 Q49A56
PDB IDs		1UPT 4DCN 5EE5 5J5C	1R4A 1UPT
Enriched GO Terms of Interacting Partners?		Golgi Apparatus Golgi Membrane Trans-Golgi Network Small GTPase Binding Golgi To Plasma Membrane Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Intracellular Protein Localization Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Secretion Vesicle-mediated Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Acrosomal Vesicle Cytosol Vesicle-mediated Transport To The Plasma Membrane Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Recycling Endosome To Golgi Transport Intracellular Protein Transport Membrane Curvature Sensor Activity Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Developmental Growth Late Endosome To Golgi Transport Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell	Endosome To Plasma Membrane Transport Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Cellular Localization Trans-Golgi Network Membrane Ciliary Basal Body Intracellular Transport Microtubule-based Movement Protein Localization To Golgi Apparatus Establishment Of Localization In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Projection Organization Cytoplasm Organelle Organization Protein Transport Microtubule Binding Intraciliary Transport Cyclin D2-CDK6 Complex Peptidyl-cysteine Methylation Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vesicle-mediated Transport Protein Localization To Organelle Centrosome Golgi Vesicle Transport Golgi To Plasma Membrane Transport Glial Cell Development Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Projection Golgi Apparatus GTPase Activity Establishment Of Protein Localization Phospholipase D Activator Activity Protein Localization To Membrane Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Broken Chromosome Clustering Serine-type Endopeptidase Inhibitor Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Endothelin Production
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