ARL1 and GOLGA1

Number of citations: 37 (PubMedID 12972563)
Data Source: BioGRID (two hybrid, two hybrid, pull down), HPRD (in vitro, in vivo, two hybrid)

		ARL1	GOLGA1
Name		ARF like GTPase 1	golgin A1
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Activator Activity Protein Domain Specific Binding Metal Ion Binding Phospholipase D Activator Activity	Protein Binding Molecular Carrier Activity
	Biological Process	Intracellular Protein Transport Golgi Organization Toxin Metabolic Process Vesicle-mediated Transport Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi	Cell-cell Adhesion Mediated By Cadherin Transepithelial Transport
Pathways		Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network
Drugs		Guanosine-5'-Diphosphate	None
GWAS		Lung cancer in never smokers ( 28604730 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: ARFIP2 COPG2 DRD2 GCC1 GCC2 GOLGA1 GOLGA4 SCOC	22 interacting genes: ARL1 ATF4 ATXN10 CEP57L1 EFHC2 EXOC4 HSF2BP KIAA1328 KIFC3 KRT27 LZTS1 PDCL2 PPP1R13B PRKAR1B RAB6A SLAIN1 TFIP11 TP53BP2 UBE2I VPS52 ZC2HC1C ZNF774
Entrez ID		400	2800
HPRD ID		04574	03934
Ensembl ID		ENSG00000120805	ENSG00000136935
Uniprot IDs		B4DZG7 P40616	Q92805
PDB IDs		1UPT 4DCN 5EE5 5J5C	Not available
GO Terms Enriched among Interactors		Golgi Apparatus Golgi Membrane Trans-Golgi Network Small GTPase Binding Golgi To Plasma Membrane Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Intracellular Protein Localization Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Secretion Vesicle-mediated Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Acrosomal Vesicle Cytosol Vesicle-mediated Transport To The Plasma Membrane Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Recycling Endosome To Golgi Transport Intracellular Protein Transport Membrane Curvature Sensor Activity Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Developmental Growth Late Endosome To Golgi Transport Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell	None