CDC42EP4 and RHOQ

Number of citations of the paper that reports this interaction (PubMedID 10490598)
56

Data Source:
HPRD (two hybrid, in vitro)

		CDC42EP4	RHOQ
Description		CDC42 effector protein 4	ras homolog family member Q
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Endomembrane System Actin Cytoskeleton Microtubule Cytoskeleton Membrane Phagocytic Vesicle	Cytoplasm Actin Filament Plasma Membrane Membrane Golgi-associated Vesicle Membrane Membrane Raft Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding Profilin Binding GTP Binding Protein Kinase Binding GBD Domain Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Cellular Response To Type II Interferon	Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Establishment Of Cell Polarity Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: APP CDC42 FAM9B LNX1 RHOQ SRPK2 TGFBR1 WDR6	22 interacting genes: BANP CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC MORN4 NTAQ1 PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL ZNF417
Entrez ID		23580	23433
HPRD ID		08383	05791
Ensembl ID		ENSG00000179604	ENSG00000119729
Uniprot IDs		B2R6D8 Q9H3Q1	P17081 V9HWD0
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Filopodium Assembly GBD Domain Binding Regulation Of Filopodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Filopodium Assembly Positive Regulation Of Supramolecular Fiber Organization Membrane Raft Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Organization Postsynapse Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell Cycle Positive Regulation Of Neuron Apoptotic Process Regulation Of Actin Cytoskeleton Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction System Development Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Endocytosis Lipoprotein Particle Cell Junction Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Establishment Of Cell Polarity	Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm PAR Polarity Complex Positive Regulation Of Protein Polymerization Cytosol Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Small GTPase Binding Rho Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Tight Junction Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Regulation Of Cell Shape Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Cell Leading Edge Regulation Of Actin Cytoskeleton Organization Cell Cortex Actin Cytoskeleton Organization Plasma Membrane COPI Vesicle Coat Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament-based Process COPI-coated Vesicle Membrane Regulation Of Protein-containing Complex Assembly Regulation Of Cell Morphogenesis Cell Junction Organization Endomembrane System Positive Regulation Of Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Bicellular Tight Junction Membrane Coat Intracellular Signaling Cassette Centriolar Satellite
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