CDC42EP4 and RHOQ

Number of citations of the paper that reports this interaction (PMID 10490598)
24

Data Source:
HPRD (two hybrid, in vitro)

		CDC42EP4	RHOQ
Gene Name		CDC42 effector protein (Rho GTPase binding) 4	ras homolog family member Q
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Actin Cytoskeleton Microtubule Cytoskeleton	Cytosol Actin Filament Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Rho GTPase Activator Activity GTP-Rho Binding Poly(A) RNA Binding	GTPase Activity Profilin Binding GTP Binding GBD Domain Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity	Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			Rho GTPase cycle Signaling by Rho GTPases Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP CDC42 FAM9B LNX1 RHOQ SRPK2 TGFBR1 WDR6	18 interactors: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL
Entrez ID		23580	23433
HPRD ID		08383	05791
Ensembl ID		ENSG00000179604
Uniprot IDs		B2R6D8 B3KUS7 Q9H3Q1	P17081
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		Regulation Of Filopodium Assembly Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Regulation Of Protein Binding Positive Regulation Of Gene Expression Positive Regulation Of Filopodium Assembly Regulation Of Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis Angiogenesis Positive Regulation Of Neuron Apoptotic Process Blood Vessel Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Neuron Fate Commitment Regulation Of ERBB Signaling Pathway Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nuclear Speck Organization Regulation Of Synapse Structure Or Activity Blood Vessel Development Vasculature Development Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Establishment Of Protein Localization Cell Cycle Arrest Response To Wounding Submandibular Salivary Gland Formation Collateral Sprouting In Absence Of Injury Actin Filament Branching Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Protein Localization Regulation Of Kinase Activity	Positive Regulation Of Cell Projection Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Golgi Vesicle Budding Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Membrane Budding Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Cellular Component Size Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Small GTPase Mediated Signal Transduction Localization Within Membrane Vesicle-mediated Transport Actin Filament-based Process Positive Regulation Of Hydrolase Activity Regulation Of Cell Shape Tight Junction Assembly Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Cell Junction Assembly Regulation Of GTPase Activity Vesicle Organization Cell-cell Junction Organization Ras Protein Signal Transduction Apical Junction Assembly Organelle Organization Positive Regulation Of Rho GTPase Activity COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Organelle Organization Regulation Of Ras GTPase Activity Golgi Vesicle Transport Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity
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