CDC42EP4 and SRPK2

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		CDC42EP4	SRPK2
Gene Name		CDC42 effector protein (Rho GTPase binding) 4	SRSF protein kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Actin Cytoskeleton Microtubule Cytoskeleton	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Rho GTPase Activator Activity GTP-Rho Binding Poly(A) RNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088)
Protein-Protein Interactions		8 interactors: APP CDC42 FAM9B LNX1 RHOQ SRPK2 TGFBR1 WDR6	177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9
Entrez ID		23580	6733
HPRD ID		08383	04280
Ensembl ID		ENSG00000179604	ENSG00000135250
Uniprot IDs		B2R6D8 B3KUS7 Q9H3Q1	P78362
PDB IDs			2X7G
Enriched GO Terms of Interacting Partners?		Regulation Of Filopodium Assembly Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Regulation Of Protein Binding Positive Regulation Of Gene Expression Positive Regulation Of Filopodium Assembly Regulation Of Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis Angiogenesis Positive Regulation Of Neuron Apoptotic Process Blood Vessel Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Neuron Fate Commitment Regulation Of ERBB Signaling Pathway Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nuclear Speck Organization Regulation Of Synapse Structure Or Activity Blood Vessel Development Vasculature Development Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Establishment Of Protein Localization Cell Cycle Arrest Response To Wounding Submandibular Salivary Gland Formation Collateral Sprouting In Absence Of Injury Actin Filament Branching Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Protein Localization Regulation Of Kinase Activity	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?			70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Difference) ?			70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Intersection) ?