CDC42EP4 and WDR6

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC42EP4	WDR6
Description		CDC42 effector protein 4	WD repeat domain 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Endomembrane System Actin Cytoskeleton Microtubule Cytoskeleton Membrane Phagocytic Vesicle	Cytoplasm Cytosol Plasma Membrane COP9 Signalosome
	Molecular Function	RNA Binding Protein Binding Small GTPase Binding	TRNA Binding RNA Binding Protein Binding Enzyme Regulator Activity
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Cellular Response To Type II Interferon	Wobble Position Ribose Methylation TRNA Processing Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation G1 To G0 Transition
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Menarche (age at onset) ( 25231870) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: APP CDC42 FAM9B LNX1 RHOQ SRPK2 TGFBR1 WDR6	6 interacting genes: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 UBC
Entrez ID		23580	11180
HPRD ID		08383	06912
Ensembl ID		ENSG00000179604	ENSG00000178252
Uniprot IDs		B2R6D8 Q9H3Q1	A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Filopodium Assembly GBD Domain Binding Regulation Of Filopodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Filopodium Assembly Positive Regulation Of Supramolecular Fiber Organization Membrane Raft Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Organization Postsynapse Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell Cycle Positive Regulation Of Neuron Apoptotic Process Regulation Of Actin Cytoskeleton Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction System Development Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Endocytosis Lipoprotein Particle Cell Junction Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Establishment Of Cell Polarity	Regulation Of Fatty Acid Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Lipid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Intracellular Signal Transduction Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Regulation Of Fatty Acid Metabolic Process Response To Vitamin B3 SREBP-SCAP Complex Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Post-translational Protein Modification Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Regulation Of Anatomical Structure Morphogenesis BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Regulation Of Ketone Metabolic Process Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation DNA Strand Resection Involved In Replication Fork Processing Ubiquitin-protein Transferase Activity Regulation Of Lipid Biosynthetic Process Protein Ubiquitination DNA Repair Complex Random Inactivation Of X Chromosome Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Protein Tag Activity Sterol Binding Response To Sterol Depletion Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Endomembrane System Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
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