PRAME and ZNF408

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		PRAME	ZNF408
Description		PRAME nuclear receptor transcriptional regulator	zinc finger protein 408
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Plasma Membrane Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Protein Binding Nuclear Retinoic Acid Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Femoral neck bone mineral density ( 29499414) Schizophrenia ( 29483656)
Interacting Genes		9 interacting genes: ELOB ELOC FBXO7 RARA RBX1 UBC WHR1 XRN2 ZNF408	83 interacting genes: AEBP2 AEN APOBEC3C ATRN BAHD1 CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 CYSRT1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 FHL5 FSD2 GIPC1 GPATCH2L HNRNPK HOXA5 HOXB9 ID3 KCTD9 KHDRBS3 KRT40 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP4-12 KRTAP5-9 LDOC1 LSM2 LZTS2 MDFI MID2 MIF MRRF MTUS2 NBPF19 NOTCH2NLA PDE4DIP PDLIM4 PICK1 PNMA2 PRAME PRNP PRPF31 PSTPIP1 RALY RALYL RBM10 RBMY1F RBMY1J SAP30BP SPRED1 SSX2IP THAP1 TLE5 TOP3B TRIM23 TRIM41 UBE2I UPF2 USP20 ZBTB26 ZBTB48 ZBTB8A ZBTB9 ZC4H2 ZNF212 ZNF317 ZNF330 ZNF331 ZNF473 ZNF526 ZNF764 ZNF792 ZNF837 ZRANB1
Entrez ID		23532	79797
HPRD ID		05820	18338
Ensembl ID		ENSG00000185686	ENSG00000175213
Uniprot IDs		B7Z7K8 B7Z986 B7ZAT0 P78395	B4DXY4 Q9H9D4
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex VCB Complex Target-directed MiRNA Degradation Elongin Complex RNA Catabolic Process Modification-dependent Protein Catabolic Process Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding MiRNA Catabolic Process Ubiquitin Ligase Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Post-translational Protein Modification Negative Regulation Of MiRNA-mediated Gene Silencing Nucleobase-containing Compound Biosynthetic Process Post-transcriptional Gene Silencing Protein Modification Process MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Nucleus Proteolysis Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Macromolecule Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Regulation Of Mitophagy Transcription Corepressor Binding Regulation Of Autophagy Of Mitochondrion RNA Metabolic Process DNA-templated Transcription Elongation Macromolecule Biosynthetic Process SCF Ubiquitin Ligase Complex Sertoli Cell Fate Commitment Positive Regulation Of Single Strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Nucleobase-containing Compound Metabolic Process Hippocampus Development Autophagy Of Mitochondrion	Identical Protein Binding Nucleus Protein Binding Zinc Ion Binding Intermediate Filament Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex MRNA Processing Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Muramyl Dipeptide
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