PRAME and STK19

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		PRAME	STK19
Gene Name		preferentially expressed antigen in melanoma	serine/threonine kinase 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Nucleus
	Molecular Function	Protein Binding Retinoic Acid Receptor Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Cell Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	Protein Phosphorylation
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23577725) Hematology traits ( 23263863) Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: CUL2 RARA RBX1 STK19 TCEB1 TCEB2 UBC XRN2 ZNF408	8 interactors: BHLHE40 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TRIM23
Entrez ID		23532	8859
HPRD ID		05820	07281
Ensembl ID		ENSG00000185686	ENSG00000204344
Uniprot IDs		F5H4B1 P78395	P49842
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Viral Process Cellular Macromolecule Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Viral Transcription Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Sertoli Cell Fate Commitment DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Notch Signaling Pathway	Nucleobase-containing Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Uridine Transport Regulation Of MRNA Processing Nucleotide-excision Repair Pyrimidine Nucleoside Transport Cellular Metabolic Process RNA Metabolic Process Base-excision Repair, Gap-filling Transcription From RNA Polymerase II Promoter Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Embryonic Process Involved In Female Pregnancy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Enucleate Erythrocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Granulocyte Differentiation Sleep DNA Synthesis Involved In DNA Repair RNA Splicing Nucleotide-excision Repair, DNA Gap Filling Regulation Of MRNA 3'-end Processing Nucleoside Transmembrane Transport Monocyte Differentiation Nucleoside Transport Natural Killer Cell Differentiation Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Metabolic Process Megakaryocyte Differentiation Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gene Expression Definitive Hemopoiesis Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Biosynthetic Process
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned	acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma melanomas nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte p15 pbl permitted pointing ref tab trp tyrosinase uncloned	acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib
Tagcloud (Intersection) ?		melanomas