PRAME and WHR1

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		PRAME	WHR1
Description		PRAME nuclear receptor transcriptional regulator	winged helix repair factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Plasma Membrane Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Nuclear Retinoic Acid Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Double-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Serine/threonine Kinase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Polyubiquitination Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	DNA Repair DNA Damage Response Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Single Strand Break Repair
Pathways
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: ELOB ELOC FBXO7 RARA RBX1 UBC WHR1 XRN2 ZNF408	13 interacting genes: BHLHE40 MAB21L3 PFDN5 PICK1 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TBRG4 TRIM23 VIM
Entrez ID		23532	8859
HPRD ID		05820	07281
Ensembl ID		ENSG00000185686	ENSG00000204344
Uniprot IDs		B7Z7K8 B7Z986 B7ZAT0 P78395	A0A1U9X8L3 P49842
PDB IDs			7XRB 8YCM 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex VCB Complex Target-directed MiRNA Degradation Elongin Complex RNA Catabolic Process Modification-dependent Protein Catabolic Process Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding MiRNA Catabolic Process Ubiquitin Ligase Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Post-translational Protein Modification Negative Regulation Of MiRNA-mediated Gene Silencing Nucleobase-containing Compound Biosynthetic Process Post-transcriptional Gene Silencing Protein Modification Process MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Nucleus Proteolysis Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Macromolecule Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Regulation Of Mitophagy Transcription Corepressor Binding Regulation Of Autophagy Of Mitochondrion RNA Metabolic Process DNA-templated Transcription Elongation Macromolecule Biosynthetic Process SCF Ubiquitin Ligase Complex Sertoli Cell Fate Commitment Positive Regulation Of Single Strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Nucleobase-containing Compound Metabolic Process Hippocampus Development Autophagy Of Mitochondrion
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