CLCF1 and S100A6

Number of citations of the paper that reports this interaction (PubMedID 34933172)
0

Data Source:
BioGRID (pull down)

		CLCF1	S100A6
Description		cardiotrophin like cytokine factor 1	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space CRLF-CLCF1 Complex CNTFR-CLCF1 Complex	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity Receptor Ligand Activity	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation Cell Surface Receptor Signaling Pathway Via STAT	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		IL-6-type cytokine receptor ligand interactions
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		5 interacting genes: CNTFR CRLF1 S100A1 S100A6 S100P	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		23529	6277
HPRD ID		09643	00237
Ensembl ID		ENSG00000175505	ENSG00000197956
Uniprot IDs		Q9UBD9	P06703
PDB IDs		8D7H 8D7R	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Cell Population Proliferation Calcium-dependent Protein Binding Regulation Of Motor Neuron Apoptotic Process S100 Protein Binding Cytokine Binding Regulation Of Cell Population Proliferation Cytokine Receptor Activity Cytokine-mediated Signaling Pathway Interleukin-11 Receptor Activity Negative Regulation Of Neuron Apoptotic Process CNTFR-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Regulation Of Oligodendrocyte Progenitor Proliferation Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Cytoplasmic Side Of Plasma Membrane SH3 Domain Binding Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Interleukin-5-mediated Signaling Pathway Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Protein Homodimerization Activity Calcium Ion Binding Ciliary Neurotrophic Factor Receptor Binding CRLF-CLCF1 Complex Synaptic Receptor Adaptor Activity Interleukin-11-mediated Signaling Pathway Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Brainstem Development Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Histamine Transport Suckling Behavior	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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