TRAM1 and TICAM1

Number of citations of the paper that reports this interaction (PMID 12721283)
20

Data Source:
HPRD (in vivo)

		TRAM1	TICAM1
Gene Name		translocation associated membrane protein 1	toll-like receptor adaptor molecule 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol Endosome Membrane Ripoptosome
	Molecular Function	Receptor Activity Protein Binding	Signal Transducer Activity Protein Binding Protein Kinase Binding
	Biological Process	Translation Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Cellular Protein Metabolic Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway
Pathways		Translation SRP-dependent cotranslational protein targeting to membrane	TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)	Vitiligo ( 22561518)
Protein-Protein Interactions		8 interactors: APP ESR1 ESR2 SEC61B TICAM1 TIRAP TRAF6 VKORC1	23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1
Entrez ID		23471	148022
HPRD ID		05545	06350
Ensembl ID		ENSG00000067167	ENSG00000127666
Uniprot IDs		G3XAN4 Q15629 Q6FHL3	Q8IUC6
PDB IDs			3RC4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Response To Lipid Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Vagina Development Positive Regulation Of Interleukin-6 Biosynthetic Process Uterus Development Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Protein Binding Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Homodimerization Activity Female Genitalia Development Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Prostate Gland Epithelium Morphogenesis Prostate Gland Morphogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Cell Proliferation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Organ Development Positive Regulation Of Interleukin-12 Production Positive Regulation Of Cell Activation	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death
Tagcloud ?		3beta alleviating augmented chop contributor crosstalk droplets endoplasmic facilitating ffas fundamental g6pase gluconeogenic grp78 gsk hepg2 hfd hyperactivation initiating jnk knocking pa palmitate pepck played resident sp600125 tendency translocating	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Difference) ?		3beta alleviating augmented chop contributor crosstalk droplets endoplasmic facilitating ffas fundamental g6pase gluconeogenic grp78 gsk hepg2 hfd hyperactivation initiating jnk knocking pa palmitate pepck played resident sp600125 tendency translocating	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Intersection) ?