TRAM1 and SEC61B

Number of citations of the paper that reports this interaction (PubMedID 9512475)
33

Data Source:
HPRD (in vivo)

		TRAM1	SEC61B
Description		translocation associated membrane protein 1	SEC61 translocon subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Signaling Receptor Activity	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Response To Unfolded Protein Protein Transport Protein Insertion Into ER Membrane	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway
Pathways		SRP-dependent cotranslational protein targeting to membrane	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1
Entrez ID		23471	10952
HPRD ID		05545	06715
Ensembl ID		ENSG00000067167	ENSG00000106803
Uniprot IDs		G3XAN4 Q15629 Q6FHL3	P60468
PDB IDs			6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Metabolic Process Nuclear Estrogen Receptor Activity Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipid Response To Lipid Regulation Of Defense Response Positive Regulation Of Chemokine Production Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokine Production Signaling Adaptor Activity Estrogen Response Element Binding TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Leukocyte Chemotaxis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of JNK Cascade Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurotransmitter Uptake Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Nuclear Steroid Receptor Activity Intracellular Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation	Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization
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