SIRT3 and XRCC6

Number of citations of the paper that reports this interaction (PMID 18710944)
99

Data Source:
BioGRID (enzymatic study)

		SIRT3	XRCC6
Gene Name		sirtuin 3	X-ray repair complementing defective repair in Chinese hamster cells 6
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD+ Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Organelle Organization Mitochondrion Organization Aging Aerobic Respiration Peptidyl-lysine Deacetylation Histone H3 Deacetylation	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways		Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS		Uterine fibroids ( 21460842)
Protein-Protein Interactions		4 interactors: DNM1L HSPD1 PEX5 XRCC6	126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B
Entrez ID		23410	2547
HPRD ID		06836	01071
Ensembl ID		ENSG00000142082	ENSG00000196419
Uniprot IDs		E9PK80 E9PM75 E9PN58 Q9NTG7	B1AHC8 B1AHC9 P12956
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9	1JEQ 1JEY 1JJR 3RZX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Protein Tetramerization Mitochondrial Membrane Fission B Cell Cytokine Production Dynamin Polymerization Involved In Mitochondrial Fission Isotype Switching To IgG Isotypes Protein Complex Assembly Negative Regulation Of Protein Homotetramerization Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Import Into Peroxisome Matrix, Translocation Cellular Hyperosmotic Salinity Response Regulation Of Peroxisome Organization DNA Recombination Protein Import Into Peroxisome Matrix, Docking Cellular Response To X-ray Negative Regulation Of Protein Homooligomerization Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane Protein To Membrane Docking Establishment Of Integrated Proviral Latency Cellular Protein Complex Assembly Positive Regulation Of Cytokine Production Peroxisomal Membrane Transport Positive Regulation Of Immune Response To Tumor Cell Cellular Hyperosmotic Response Positive Regulation Of Mitochondrial Fission Hyperosmotic Salinity Response Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Protein Oligomerization Establishment Of Viral Latency Mitochondrion Organization Anatomical Structure Development Peroxisome Fission Cellular Response To Salt Stress Positive Regulation Of Macrophage Activation Protein Oligomerization Cellular Component Assembly Regulation Of Mitochondrial Fission Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Cytokine Production Involved In Immune Response DNA Ligation Protein Localization To Organelle Developmental Process Regulation Of Cytokine Production Positive Regulation Of Interferon-alpha Production Viral Process	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Difference) ?		acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Intersection) ?