SIRT3 and GLDC

Number of citations of the paper that reports this interaction (PubMedID 34244482)
33

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		SIRT3	GLDC
Description		sirtuin 3	glycine decarboxylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent Enzyme Binding Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Sequence-specific DNA Binding Metal Ion Binding NAD+ Binding NAD-dependent Protein Lysine Delactylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Oxidoreductase Activity Glycine Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Protein Deacetylation Aerobic Respiration Positive Regulation Of Insulin Secretion Cellular Response To Stress Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Amino Acid Metabolic Process Glycine Metabolic Process Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Methylamine Response To Lipoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Mitochondrial unfolded protein response (UPRmt) Maturation of TCA enzymes and regulation of TCA cycle	Glycine degradation
Drugs		Adenosine-5-Diphosphoribose	Pyridoxal phosphate
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)	Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 30837465 31070104) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		11 interacting genes: ALDH2 DNM1L ECHS1 GLDC H3C1 MCL1 MDM2 PDP1 PEX5 PYCR1 XRCC6	2 interacting genes: SIRT3 TLR10
Entrez ID		23410	2731
HPRD ID		06836	01996
Ensembl ID		ENSG00000142082	ENSG00000178445
Uniprot IDs		E9PK80 E9PM75 E9PN58 Q9NTG7	P23378
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO 8ANC 8BBK 8CCW 8CCZ 8HLW 8HLY 8HN9 8V15 8V2N 8V5U 9CBT	6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Matrix Cellular Response To Chemical Stress Protein-containing Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Lyase Activity Cellular Response To Gamma Radiation Electron Transfer Activity Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process 3-hydroxypropionyl-CoA Dehydratase Activity Fatty Acid Beta-oxidation Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Response To Gamma Radiation Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Formaldehyde Cellular Response To Oxidative Stress Cellular Response To Vitamin B1 Endoplasmic Reticulum Organization Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Carboxylic Acid Metabolic Process Apoptotic Mitochondrial Changes Organic Acid Metabolic Process Cellular Response To Ionizing Radiation Small Molecule Metabolic Process Fatty Acid Catabolic Process Crotonyl-CoA Hydratase Activity Fatty Acid Oxidation Response To Lipoic Acid Protein Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Lipid Oxidation Response To Oxidative Stress DNA End Binding Cellular Response To Stress Ku70:Ku80 Complex Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Glycine Catabolic Process	Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Toll-like Receptor 2 Binding Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Histone Deacetylase Activity, NAD-dependent Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cellular Respiration Positive Regulation Of Ceramide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Sphingolipid Biosynthetic Process Dynein Heavy Chain Binding Dynein Light Chain Binding Outer Dynein Arm Cellular Response To Bacterial Lipopeptide NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding Response To Bacterial Lipoprotein NAD+ Binding Regulation Of Oxidoreductase Activity Dynein Axonemal Particle Outer Dynein Arm Assembly Regulation Of Membrane Lipid Metabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Phosphorylation Cytokine Receptor Binding Macromolecule Deacylation Glial Cell Projection NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Aerobic Respiration Positive Regulation Of Amide Metabolic Process 9+2 Motile Cilium Innate Immune Response Dynein Complex Axonemal Dynein Complex Assembly Response To Exogenous DsRNA Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Reactive Oxygen Species Metabolic Process
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