SIRT3 and DNM1L

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SIRT3	DNM1L
Description		sirtuin 3	dynamin 1 like
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Endomembrane System Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Mitochondrion-derived Vesicle
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent Enzyme Binding Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Sequence-specific DNA Binding Metal Ion Binding NAD+ Binding NAD-dependent Protein Lysine Delactylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Deacetylation Aerobic Respiration Positive Regulation Of Insulin Secretion Cellular Response To Stress Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Mitochondrial Fission Calcium Ion Transport Endocytosis Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Gene Expression Regulation Of Mitochondrion Organization Programmed Cell Death Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Distribution Of Mitochondria Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Mitocytosis Regulation Of Peroxisome Organization Regulation Of Mitophagy Positive Regulation Of Secretion By Cell Regulation Of ATP Metabolic Process
Pathways		Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Mitochondrial unfolded protein response (UPRmt) Maturation of TCA enzymes and regulation of TCA cycle	Apoptotic execution phase
Drugs		Adenosine-5-Diphosphoribose
Diseases
GWAS		Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)	Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		11 interacting genes: ALDH2 DNM1L ECHS1 GLDC H3C1 MCL1 MDM2 PDP1 PEX5 PYCR1 XRCC6	23 interacting genes: CAP2 FILNC1 FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 USP16 VIM ZBTB24
Entrez ID		23410	10059
HPRD ID		06836	04833
Ensembl ID		ENSG00000142082	ENSG00000087470
Uniprot IDs		E9PK80 E9PM75 E9PN58 Q9NTG7	B4DYR6 O00429
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO 8ANC 8BBK 8CCW 8CCZ 8HLW 8HLY 8HN9 8V15 8V2N 8V5U 9CBT	3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9 8T1H
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Matrix Cellular Response To Chemical Stress Protein-containing Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Lyase Activity Cellular Response To Gamma Radiation Electron Transfer Activity Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process 3-hydroxypropionyl-CoA Dehydratase Activity Fatty Acid Beta-oxidation Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Response To Gamma Radiation Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Formaldehyde Cellular Response To Oxidative Stress Cellular Response To Vitamin B1 Endoplasmic Reticulum Organization Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Carboxylic Acid Metabolic Process Apoptotic Mitochondrial Changes Organic Acid Metabolic Process Cellular Response To Ionizing Radiation Small Molecule Metabolic Process Fatty Acid Catabolic Process Crotonyl-CoA Hydratase Activity Fatty Acid Oxidation Response To Lipoic Acid Protein Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Lipid Oxidation Response To Oxidative Stress DNA End Binding Cellular Response To Stress Ku70:Ku80 Complex Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Glycine Catabolic Process	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Mitochondrial Outer Membrane Peroxisome Positive Regulation Of Organelle Organization Positive Regulation Of Type 2 Mitophagy Regulation Of Mitochondrial Fusion Cellular Response To Toxic Substance Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitophagy Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrial Fusion Response To Hydrogen Sulfide Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Modification Process Lewy Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitophagy Negative Regulation Of Mitochondrial Fusion Ubiquitin Protein Ligase Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Positive Regulation Of Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Post-translational Protein Modification Regulation Of Protein Metabolic Process
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