SIRT3 and DNM1L

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SIRT3	DNM1L
Gene Name		sirtuin 3	dynamin 1-like
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Golgi Apparatus Cytosol Microtubule Coated Pit Membrane Cell Junction Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD+ Binding	GTPase Activity Protein Binding GTP Binding Lipid Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Organelle Organization Mitochondrion Organization Aging Aerobic Respiration Peptidyl-lysine Deacetylation Histone H3 Deacetylation	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Dynamin Polymerization Involved In Mitochondrial Fission Endocytosis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Mitochondrion Organization Peroxisome Fission Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Protein Secretion Protein Homotetramerization Membrane Fusion Necroptotic Process Mitochondrion Morphogenesis Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Peroxisome Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Uterine fibroids ( 21460842)
Protein-Protein Interactions		4 interactors: DNM1L HSPD1 PEX5 XRCC6	15 interactors: FIS1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF2 MUL1 PARK2 RRM2 SCG3 SH3GL1 SIRT3 VIM ZBTB24
Entrez ID		23410	10059
HPRD ID		06836	04833
Ensembl ID		ENSG00000142082	ENSG00000087470
Uniprot IDs		E9PK80 E9PM75 E9PN58 Q9NTG7	B4DGC9 B4DYR6 G8JLD5 J3KPI2 O00429 Q59GN9
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9	4BEJ 4H1U 4H1V
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Protein Tetramerization Mitochondrial Membrane Fission B Cell Cytokine Production Dynamin Polymerization Involved In Mitochondrial Fission Isotype Switching To IgG Isotypes Protein Complex Assembly Negative Regulation Of Protein Homotetramerization Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Import Into Peroxisome Matrix, Translocation Cellular Hyperosmotic Salinity Response Regulation Of Peroxisome Organization DNA Recombination Protein Import Into Peroxisome Matrix, Docking Cellular Response To X-ray Negative Regulation Of Protein Homooligomerization Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane Protein To Membrane Docking Establishment Of Integrated Proviral Latency Cellular Protein Complex Assembly Positive Regulation Of Cytokine Production Peroxisomal Membrane Transport Positive Regulation Of Immune Response To Tumor Cell Cellular Hyperosmotic Response Positive Regulation Of Mitochondrial Fission Hyperosmotic Salinity Response Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Protein Oligomerization Establishment Of Viral Latency Mitochondrion Organization Anatomical Structure Development Peroxisome Fission Cellular Response To Salt Stress Positive Regulation Of Macrophage Activation Protein Oligomerization Cellular Component Assembly Regulation Of Mitochondrial Fission Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Cytokine Production Involved In Immune Response DNA Ligation Protein Localization To Organelle Developmental Process Regulation Of Cytokine Production Positive Regulation Of Interferon-alpha Production Viral Process	Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Mitochondrial Fission Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Mitochondrial Fusion Regulation Of Intracellular Transport Regulation Of Mitochondrial Fusion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Apoptotic Process Protein Localization To Mitochondrion Mitochondrial Fragmentation Involved In Apoptotic Process Programmed Cell Death Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Transport Peroxisome Fission Positive Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Signal Transduction Mitochondrial Fusion Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Mitochondrion Morphogenesis Regulation Of JNK Cascade Mitochondrion Degradation Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Mitochondrion Organization Protein Localization To Organelle Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Organelle Disassembly Activation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Peroxisome Organization
Tagcloud ?		acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Difference) ?		acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins	affirmed brains compendia computationally distinctly emerges etiological etiology forests hippocampus inferred ins1 ins2 modules mutual networks neurotrophic notable orphan orthologs postmortem probable rora scheme tia1 tied ties trees unresolved
Tagcloud (Intersection) ?