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SIRT3
Description
sirtuin 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
Protein-containing Complex
Molecular Function
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
Histone Deacetylase Activity, NAD-dependent
Enzyme Binding
Protein Lysine Deacetylase Activity
NAD-dependent Protein Lysine Deacetylase Activity
Sequence-specific DNA Binding
Metal Ion Binding
NAD+ Binding
NAD-dependent Protein Lysine Delactylase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Biological Process
Protein Deacetylation
Aerobic Respiration
Positive Regulation Of Insulin Secretion
Cellular Response To Stress
Peptidyl-lysine Deacetylation
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Superoxide Dismutase Activity
Positive Regulation Of Catalase Activity
Positive Regulation Of Oxidative Phosphorylation
Positive Regulation Of Ceramide Biosynthetic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Transcriptional activation of mitochondrial biogenesis
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Regulation of FOXO transcriptional activity by acetylation
Mitochondrial unfolded protein response (UPRmt)
Maturation of TCA enzymes and regulation of TCA cycle
Drugs
Adenosine-5-Diphosphoribose
Diseases
GWAS
Coronary artery disease (
33020668
)
Glycated hemoglobin levels (
34059833
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Menarche (age at onset) (
25231870
)
Platelet count (
24026423
)
Uterine fibroids (
21460842
30194396
)
Interacting Genes
11 interacting genes:
ALDH2
DNM1L
ECHS1
GLDC
H3C1
MCL1
MDM2
PDP1
PEX5
PYCR1
XRCC6
Entrez ID
23410
HPRD ID
06836
Ensembl ID
ENSG00000142082
Uniprot IDs
E9PK80
E9PM75
E9PN58
Q9NTG7
PDB IDs
3GLR
3GLS
3GLT
3GLU
4BN4
4BN5
4BV3
4BVB
4BVE
4BVF
4BVG
4BVH
4C78
4C7B
4FVT
4FZ3
4HD8
4JSR
4JT8
4JT9
4O8Z
5BWN
5BWO
5D7N
5H4D
5Y4H
5YTK
5Z93
5Z94
5ZGC
6ISO
8ANC
8BBK
8CCW
8CCZ
8HLW
8HLY
8HN9
8V15
8V2N
8V5U
9CBT
Enriched GO Terms of Interacting Partners
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Mitochondrion
Mitochondrial Matrix
Cellular Response To Chemical Stress
Protein-containing Complex
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Lyase Activity
Cellular Response To Gamma Radiation
Electron Transfer Activity
Nitroglycerin Metabolic Process
Phenylacetaldehyde Dehydrogenase (NAD+) Activity
Regulation Of Serotonin Biosynthetic Process
3-hydroxypropionyl-CoA Dehydratase Activity
Fatty Acid Beta-oxidation
Carboxylic Acid Catabolic Process
Amino Acid Metabolic Process
Response To Gamma Radiation
Glycine Dehydrogenase (decarboxylating) Activity
Pyridoxal Binding
Response To Methylamine
Negative Regulation Of Apoptotic Signaling Pathway
Mitochondrion Organization
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Response To Formaldehyde
Cellular Response To Oxidative Stress
Cellular Response To Vitamin B1
Endoplasmic Reticulum Organization
Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex
Carboxylic Acid Metabolic Process
Apoptotic Mitochondrial Changes
Organic Acid Metabolic Process
Cellular Response To Ionizing Radiation
Small Molecule Metabolic Process
Fatty Acid Catabolic Process
Crotonyl-CoA Hydratase Activity
Fatty Acid Oxidation
Response To Lipoic Acid
Protein Transmembrane Transport
Peroxisome Membrane Targeting Sequence Binding
Peroxisome Matrix Targeting Signal-1 Binding
Mitochondrial Membrane Fission
Regulation Of Peroxisome Organization
Lipid Oxidation
Response To Oxidative Stress
DNA End Binding
Cellular Response To Stress
Ku70:Ku80 Complex
Glycine Decarboxylation Via Glycine Cleavage System
Glycine Cleavage Complex
Glycine Catabolic Process
Tagcloud
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