AGO2 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 11914277)
44

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		AGO2	GEMIN4
Description		argonaute RISC catalytic component 2	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism SiRNA Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Translation Translational Initiation Regulation Of Translation Post-embryonic Development Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing P-body Assembly Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process RNA Stabilization Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RISC Complex Assembly Regulation Of Synapse Maturation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)	Prostate cancer ( 23535732)
Interacting Genes		35 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DFFA DHX58 DICER1 GEMIN4 HIF1A-AS2 ITCH KAT5 LINC00467 MAPKAPK2 MIR145 MIR19A MIR223 MIR24-1 MIRLET7B MIRLET7I NSD2 PFKP PRKRA PSMC3 RAD51 RBBP6 RNF31 SNCA TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBC ZNF415	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		27161	50628
HPRD ID		06943	07370
Ensembl ID		ENSG00000123908	ENSG00000179409
Uniprot IDs		Q9UKV8	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U 7KI3 8D6J 8D71 8THQ 9BEZ 9BF0 9BF2 9CMP
Enriched GO Terms of Interacting Partners?		RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Catabolic Process Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process RISC-loading Complex MRNA Destabilization RNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Biosynthetic Process RISC Complex Assembly Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Stability Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Stability Pre-miRNA Processing Positive Regulation Of MRNA Metabolic Process Response To External Biotic Stimulus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production SiRNA Processing Double-stranded RNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-activating Signaling Pathway Pre-miRNA Binding MiRNA Processing Regulation Of Defense Response Positive Regulation Of Immune Response Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Recognition Receptor Signaling Pathway SiRNA Binding Regulation Of Gene Expression Response To Other Organism Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Immune System Process Activation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Macromolecule Biosynthetic Process Immune System Process	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
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