AGO2 and GEMIN4

Number of citations of the paper that reports this interaction (PMID 11914277)
256

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AGO2	GEMIN4
Gene Name		argonaute RISC catalytic component 2	gem (nuclear organelle) associated protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Ribonucleoprotein Complex Micro-ribonucleoprotein Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Vesicular Exosome Gemini Of Coiled Bodies
	Molecular Function	RNA 7-methylguanosine Cap Binding MRNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding SiRNA Binding MiRNA Binding Poly(A) RNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA	Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Initiation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Spliceosomal SnRNP Assembly RRNA Processing Gene Expression NcRNA Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		15 interactors: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 MIRLET7B MIRLET7I PFKP PRKRA TARBP2 TBK1 TBKBP1	25 interactors: AGO2 CALCOCO2 DDX20 DHX9 DMPK FLAD1 GEMIN5 GLYR1 KARS LGALS1 LGALS3 MORC4 PIAS3 RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD1 SNRPD2 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TOP1
Entrez ID		27161	50628
HPRD ID		06943	07370
Ensembl ID		ENSG00000123908	ENSG00000179409
Uniprot IDs		A4FVC0 Q9UKV8	I3L2C7 P57678 Q8WUM5
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4EI1 4EI3 4F3T
Enriched GO Terms of Interacting Partners?		Production Of SiRNA Involved In RNA Interference Posttranscriptional Gene Silencing RNA Interference Gene Silencing By RNA Gene Silencing Gene Silencing By MiRNA Cellular Response To DsRNA Targeting Of MRNA For Destruction Involved In RNA Interference Ribonucleoprotein Complex Assembly Negative Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Response To DsRNA MRNA Metabolic Process RNA Processing Pre-miRNA Processing Response To Virus Ribonucleoprotein Complex Biogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Defense Response To Virus RNA Metabolic Process Aromatic Compound Catabolic Process MRNA Catabolic Process Defense Response To Virus Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Gene Expression Catabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of Type I Interferon Production Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immune Response Response To Other Organism Defense Response Response To Biotic Stimulus Immune System Process Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Nucleobase-containing Compound Metabolic Process	Spliceosomal SnRNP Assembly RNA Processing MRNA Processing NcRNA Metabolic Process Ribonucleoprotein Complex Assembly MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Biogenesis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Neutrophil Degranulation RNA Metabolic Process Nitrogen Compound Metabolic Process Neutrophil Activation Involved In Immune Response Gene Expression Immune Response Cellular Component Assembly Neutrophil Mediated Immunity Production Of MiRNAs Involved In Gene Silencing By MiRNA Neutrophil Activation Immune System Process Leukocyte Activation Involved In Immune Response Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Leukocyte Degranulation Lysyl-tRNA Aminoacylation Negative Regulation Of Immunological Synapse Formation FAD Biosynthetic Process Positive Regulation Of Erythrocyte Aggregation Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Spliceosomal Complex Assembly Gene Silencing By RNA Cellular Metabolic Process MRNA Cleavage Involved In Gene Silencing By MiRNA Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Diadenosine Tetraphosphate Biosynthetic Process Response To DsRNA Cellular Process Vesicle Docking Membrane Docking SiRNA Loading Onto RISC Involved In RNA Interference Positive Regulation Of Mononuclear Cell Migration Mononuclear Cell Migration
Tagcloud ?		acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon	a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Difference) ?		acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon	a1 a11 a2 a4 a5 a6 accomplishments annealing annexin annexins carbohydrate conjunction cytoplasm cytoskeleton extensively galectin galectins helicase inside interacting lectin lectins outside phospholipid possesses primer summarizes synexin unwinding
Tagcloud (Intersection) ?