AGO2 and MAPKAPK2

Number of citations of the paper that reports this interaction (PubMedID 18476811)
0

Data Source:
BioGRID (enzymatic study)

		AGO2	MAPKAPK2
Description		argonaute RISC catalytic component 2	MAPK activated protein kinase 2
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Ciliary Basal Body Extracellular Exosome
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism SiRNA Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Translation Translational Initiation Regulation Of Translation Post-embryonic Development Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing P-body Assembly Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process RNA Stabilization Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RISC Complex Assembly Regulation Of Synapse Maturation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration	MAPK Cascade Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Inflammatory Response DNA Damage Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Stabilization Inner Ear Development Positive Regulation Of Macrophage Cytokine Production 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Regulation of TNFR1 signaling
Drugs			Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Age-related hearing impairment ( 34108613) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)	Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		35 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DFFA DHX58 DICER1 GEMIN4 HIF1A-AS2 ITCH KAT5 LINC00467 MAPKAPK2 MIR145 MIR19A MIR223 MIR24-1 MIRLET7B MIRLET7I NSD2 PFKP PRKRA PSMC3 RAD51 RBBP6 RNF31 SNCA TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBC ZNF415	42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1
Entrez ID		27161	9261
HPRD ID		06943	11882
Ensembl ID		ENSG00000123908	ENSG00000162889
Uniprot IDs		Q9UKV8	P49137
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U 7KI3 8D6J 8D71 8THQ 9BEZ 9BF0 9BF2 9CMP	1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6T8X 6TCA 7NRY 8XU4 8XX1
Enriched GO Terms of Interacting Partners?		RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Catabolic Process Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process RISC-loading Complex MRNA Destabilization RNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Biosynthetic Process RISC Complex Assembly Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Stability Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Stability Pre-miRNA Processing Positive Regulation Of MRNA Metabolic Process Response To External Biotic Stimulus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production SiRNA Processing Double-stranded RNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-activating Signaling Pathway Pre-miRNA Binding MiRNA Processing Regulation Of Defense Response Positive Regulation Of Immune Response Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Recognition Receptor Signaling Pathway SiRNA Binding Regulation Of Gene Expression Response To Other Organism Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Immune System Process Activation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Macromolecule Biosynthetic Process Immune System Process	Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Intracellular Signaling Cassette RNA Stabilization Regulation Of RNA Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression P38MAPK Cascade Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Oxygen Levels Regulation Of Metabolic Process Nucleus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of MRNA Stability Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Peptide RNA Metabolic Process Regulation Of MRNA Metabolic Process Animal Organ Development MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Multicellular Organismal Process Negative Regulation Of Autophagy Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Macromolecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Stress
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