AGO2 and DDX20

Number of citations of the paper that reports this interaction (PMID 11914277)
256

Data Source:
HPRD (in vitro, in vivo)

		AGO2	DDX20
Gene Name		argonaute RISC catalytic component 2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Ribonucleoprotein Complex Micro-ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Transcriptional Repressor Complex SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	RNA 7-methylguanosine Cap Binding MRNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding SiRNA Binding MiRNA Binding Poly(A) RNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA	DNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Initiation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly RNA Processing Gene Expression NcRNA Metabolic Process Positive Regulation Of Apoptotic Process Oogenesis Regulation Of Steroid Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 MIRLET7B MIRLET7I PFKP PRKRA TARBP2 TBK1 TBKBP1	31 interactors: AGO2 APP CRYAB DHX9 ETV3 GEMIN2 GEMIN4 GEMIN5 HDAC2 HDAC5 LSM2 NCOR1 NCOR2 NR0B2 PRRC2A RN7SL1 RNU1-1 RNU2-1 SIN3A SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN STXBP2 STXBP3
Entrez ID		27161	11218
HPRD ID		06943	05859
Ensembl ID		ENSG00000123908	ENSG00000064703
Uniprot IDs		A4FVC0 Q9UKV8	Q9H4N4 Q9UHI6
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4EI1 4EI3 4F3T	2OXC 3B7G
Enriched GO Terms of Interacting Partners?		Production Of SiRNA Involved In RNA Interference Posttranscriptional Gene Silencing RNA Interference Gene Silencing By RNA Gene Silencing Gene Silencing By MiRNA Cellular Response To DsRNA Targeting Of MRNA For Destruction Involved In RNA Interference Ribonucleoprotein Complex Assembly Negative Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Response To DsRNA MRNA Metabolic Process RNA Processing Pre-miRNA Processing Response To Virus Ribonucleoprotein Complex Biogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Defense Response To Virus RNA Metabolic Process Aromatic Compound Catabolic Process MRNA Catabolic Process Defense Response To Virus Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Gene Expression Catabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of Type I Interferon Production Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immune Response Response To Other Organism Defense Response Response To Biotic Stimulus Immune System Process Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Nucleobase-containing Compound Metabolic Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Ribonucleoprotein Complex Assembly MRNA Metabolic Process RNA Processing RNA Splicing Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Gene Expression NcRNA Metabolic Process Cellular Macromolecular Complex Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Component Assembly Cellular Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription RNA 3'-end Processing Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Termination Cellular Metabolic Process Transcription, DNA-templated Notch Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Neutrophil Degranulation Histone Deacetylation Protein Deacetylation Cellular Macromolecule Biosynthetic Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H4 Deacetylation Gene Silencing Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon	acting box coactivators concentrate corepressors creb ddx17 ddx5 deacetylases dexd dhx9 dissociate dp103 helicase helicases hydrolysis includes machinery members modulation multifunctional p68 p72 require rna roles shall unwind unwindases
Tagcloud (Difference) ?		acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon	acting box coactivators concentrate corepressors creb ddx17 ddx5 deacetylases dexd dhx9 dissociate dp103 helicase helicases hydrolysis includes machinery members modulation multifunctional p68 p72 require rna roles shall unwind unwindases
Tagcloud (Intersection) ?