MTUS2 and CDKN1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTUS2	CDKN1A
Description		microtubule associated scaffold protein 2	cyclin dependent kinase inhibitor 1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Intercellular Bridge	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex
	Molecular Function	Protein Binding Microtubule Binding Protein Homodimerization Activity	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity
	Biological Process		G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			Valproic acid Arsenic trioxide
Diseases			Cervical cancer
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Insomnia (caffeine-induced) ( 22754043) Obesity-related traits ( 23251661) Triptolide cytotoxicity ( 26121980)	Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)
Interacting Genes		327 interacting genes: ABHD15 ACSM1 AEN AIRIM AKT1 ANKRD11 ANKS1A ANXA2R-AS1 AQP1 ARL4A ARNT2 AXIN1 BANF2 BARD1 BCL6 BEX2 BMP7 BYSL C19orf44 C1orf216 C1orf35 C21orf58 C8orf34 CACNB3 CATIP CATSPER1 CATSPERT CBX8 CCAR1 CCDC116 CCDC120 CCDC146 CCDC17 CCDC185 CCDC187 CCDC198 CCDC60 CCHCR1 CDC20B CDC5L CDC7 CDC73 CDK18 CDK5R1 CDKL3 CDKN1A CDKN1B CEP57L1 CEP95 CERK CHIC2 CNNM3 COG2 CREB5 CRY2 CSF1 CTSZ CWF19L2 CXCL11 CXCL16 CYSLTR2 DCDC2B DCTN4 DCX DDX6 DHRS1 DLGAP4 DLGAP5 DMRT3 DOCK2 DSCR9 DTNB EHHADH EIF3D ENKD1 ENPP7 EXOC8 FAM107A FAM110A FAM124B FAM13C FAM161A FAM161B FAM74A4 FAM90A1 FASTKD5 FBXL18 FBXO34 FBXW5 FCHSD2 FHL3 FLYWCH1 FNDC11 FXR1 GADD45GIP1 GAL3ST2 GARIN5B GAS2L2 GEM GGN GNL3L GOLGA2P11 GPKOW GRAP2 GSTP1 GTF2I GTPBP10 HAPLN2 HAUS1 HBZ HCK HDAC4 HOXB5 HOXB9 HSF2 ICAM4 IL16 INO80B IQCE ITGB4 ITGB5 ITSN1 JMY JOSD1 JRK KANK2 KAT5 KIF1A KIFC3 KRT6A KRT75 KRT76 LENG1 LIMS2 LINC00636 LMO2 LMO3 LMO4 LNX1 LRR1 LYSMD1 MAGEA8 MARK4 MBD3 METTL17 MFAP1 MOS MRPL11 MTMR6 MYO15B MYOM1 MYPOP NDEL1 NDOR1 NEFL NELFE NHSL2 NTAQ1 NUBPL NUDT10 NXF1 ODAD3 ODF1 PCDHB14 PDE4DIP PDZD4 PIBF1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 PLK4 PLSCR4 POLDIP2 POLDIP3 PPHLN1 PPP1R18 PRKAA1 PRKAA2 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PTCD1 PTK7 PTPMT1 RAB3IL1 RALY RANBP3L RAP1B RASAL3 RASD1 RBM41 RCOR3 RGS2 RHPN1 RIBC2 RNF6 ROBO3 RPA1 RPL9 RPS19BP1 RTP5 SAMD4A SCEL SCNM1 SDCBP SELENOM SETD5 SH2D4A SH3RF2 SHFL SLC22A5 SLC23A1 SLC25A42 SLC25A48 SLC25A6 SLIRP SMARCD1 SMARCE1 SMG9 SNAI1 SNHG11 SNRPA SNRPB2 SNW1 SPATA8 SPATC1L SPG21 SPG7 STK16 SYT6 TACO1 TAF13 TBC1D22B TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP7 TLE5 TNIP3 TNNI1 TP53RK TRIM29 TRIM42 TSGA10IP TSHZ3 TTC23 TTLL10 TULP2 TXN2 UBC UBTFL1 USP2 USP22 UTP14C VASN WAC ZBTB16 ZBTB38 ZBTB47 ZC2HC1C ZFC3H1 ZFHX3 ZFP1 ZFP2 ZFP64 ZFYVE21 ZMAT2 ZMYND10 ZNF124 ZNF136 ZNF17 ZNF20 ZNF224 ZNF23 ZNF230 ZNF232 ZNF239 ZNF250 ZNF266 ZNF3 ZNF329 ZNF337 ZNF35 ZNF408 ZNF410 ZNF414 ZNF415 ZNF417 ZNF426 ZNF438 ZNF439 ZNF440 ZNF48 ZNF490 ZNF497 ZNF512B ZNF557 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF607 ZNF613 ZNF624 ZNF648 ZNF655 ZNF669 ZNF670 ZNF696 ZNF76 ZNF764 ZNF774 ZNF775 ZNF785 ZNF792 ZNF837 ZNF844 ZSCAN12 ZSCAN26	207 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		23281	1026
HPRD ID		11108	00298
Ensembl ID		ENSG00000132938	ENSG00000124762
Uniprot IDs		Q5JR59	P38936
PDB IDs			1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Metal Ion Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Protein K6-linked Ubiquitination Microtubule-based Process Spliceosomal Complex Lipid Droplet Disassembly	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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