MTCL1 and MARK2

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		MTCL1	MARK2
Description		microtubule crosslinking factor 1	microtubule affinity regulating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Extracellular Space Cytoplasm Cytoskeleton Spindle Microtubule Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Midbody Microtubule Bundle	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Protein Homodimerization Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Bundle Formation Chromosome Segregation Regulation Of Autophagy Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Positive Regulation Of Protein Targeting To Membrane	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		7 interacting genes: C11orf68 CLK1 MARK2 RNF10 SRPK2 TUBA1B TUBB3	31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ
Entrez ID		23255	2011
HPRD ID		11110	02753
Ensembl ID		ENSG00000168502	ENSG00000072518
Uniprot IDs		A0A8Q3SIW6 A0A8Q3WKN6 Q9Y4B5	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs			3IEC 5EAK 5KZ7 5KZ8 8TXY
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Microtubule Cytoskeleton Organization Structural Constituent Of Cytoskeleton Netrin Receptor Binding Kinase Activity Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Nuclear Speck Organization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Mitotic Cell Cycle Dorsal Root Ganglion Development Regulation Of RNA Splicing Regulation Of Neurofibrillary Tangle Assembly Transferase Activity Magnesium Ion Binding Microtubule-based Process R-loop Processing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Netrin-activated Signaling Pathway Microtubule Cytoskeleton	Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding
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