MTCL1 and C11orf68

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTCL1	C11orf68
Description		microtubule crosslinking factor 1	chromosome 11 open reading frame 68
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Extracellular Space Cytoplasm Cytoskeleton Spindle Microtubule Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Midbody Microtubule Bundle
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Protein Homodimerization Activity	RNA Binding Protein Binding
	Biological Process	Microtubule Bundle Formation Chromosome Segregation Regulation Of Autophagy Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Positive Regulation Of Protein Targeting To Membrane
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560)	Acne (severe) ( 24927181) Asthma ( 31959851)
Interacting Genes		7 interacting genes: C11orf68 CLK1 MARK2 RNF10 SRPK2 TUBA1B TUBB3	14 interacting genes: CSDE1 EIF4H KCNE3 KLF15 MEOX2 MTCL1 NONO PHETA1 REL SDCBP SH3GL3 TRAPPC2L ZNF341 ZNF512B
Entrez ID		23255	83638
HPRD ID		11110	12553
Ensembl ID		ENSG00000168502	ENSG00000175573
Uniprot IDs		A0A8Q3SIW6 A0A8Q3WKN6 Q9Y4B5	Q9H3H3
PDB IDs			1ZTP 2Q4K
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Microtubule Cytoskeleton Organization Structural Constituent Of Cytoskeleton Netrin Receptor Binding Kinase Activity Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Nuclear Speck Organization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Mitotic Cell Cycle Dorsal Root Ganglion Development Regulation Of RNA Splicing Regulation Of Neurofibrillary Tangle Assembly Transferase Activity Magnesium Ion Binding Microtubule-based Process R-loop Processing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Netrin-activated Signaling Pathway Microtubule Cytoskeleton
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