OTUD3 and HSPA5

Number of citations of the paper that reports this interaction (PubMedID 31266968)
44

Data Source:
BioGRID (pull down)

		OTUD3	HSPA5
Description		OTU deubiquitinase 3	heat shock protein family A (Hsp70) member 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs			Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)	Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3	77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB
Entrez ID		23252	3309
HPRD ID		19417	00682
Ensembl ID		ENSG00000169914	ENSG00000044574
Uniprot IDs		Q5T2D3	P11021 V9HWB4
PDB IDs		4BOU	3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan	Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding
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